US 12,102,615 B2
Synthesis of novel xylose free occidiofungin analogues and methods of using them
James L. Smith, Bryan, TX (US); Mengxin Geng, Beijing (CN); Akshaya Ravichandran, Palm Beach Gardens, FL (US); and Ravi Orugunty, Round Rock, TX (US)
Assigned to THE TEXAS A&M UNIVERSITY SYSTEM, College Station, TX (US); and SANO CHEMICALS, Bryan, TX (US)
Appl. No. 17/045,283
Filed by THE TEXAS A&M UNIVERSITY SYSTEM, College Station, TX (US); and SANO CHEMICALS, Bryan, TX (US)
PCT Filed Apr. 5, 2019, PCT No. PCT/US2019/025989
§ 371(c)(1), (2) Date Oct. 5, 2020,
PCT Pub. No. WO2019/195678, PCT Pub. Date Oct. 10, 2019.
Claims priority of provisional application 62/653,253, filed on Apr. 5, 2018.
Prior Publication US 2021/0169846 A1, Jun. 10, 2021
Int. Cl. A61K 31/395 (2006.01); A61K 38/12 (2006.01); A61P 43/00 (2006.01); C07K 7/56 (2006.01); C07K 7/60 (2006.01); C07K 7/64 (2006.01)
CPC A61K 31/395 (2013.01) [A61K 38/12 (2013.01); A61P 43/00 (2018.01); C07K 7/56 (2013.01); C07K 7/60 (2013.01); C07K 7/64 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A compound or salt thereof selected from the group consisting of:
a) a compound of Formula II or a salt thereof:

OG Complex Work Unit Chemistry
b) a compound of Formula III or a salt thereof:

OG Complex Work Unit Chemistry
and wherein R4 or R5 of Formula III is independently H, OH, a substituted or unsubstituted alkane, substituted or unsubstituted alkene, substituted or unsubstituted alkyne, substituted or unsubstituted aryl, substituted or unsubstituted heterocycle, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocycle, substituted or unsubstituted ether, substituted or unsubstituted thioether, substituted or unsubstituted ketone, dihydrosphingosine, or a halogen;
c) a compound of Formula IV or a salt thereof:

OG Complex Work Unit Chemistry
d) a compound of Formula V or a salt thereof:

OG Complex Work Unit Chemistry
and R4 or R5 are independently H, OH, a substituted or unsubstituted alkane, substituted or unsubstituted alkene, substituted or unsubstituted alkyne, substituted or unsubstituted aryl, substituted or unsubstituted heterocycle, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocycle, substituted or unsubstituted ether, substituted or unsubstituted thioether, substituted or unsubstituted ketone or a halogen.