US 12,102,432 B2
Uses of transdermal glomerular filtration rate measurement in continuous renal replacement therapy
Stuart L. Goldstein, Cincinnati, OH (US); and Richard B. Dorshow, Creve Coeur, MO (US)
Assigned to MEDIBEACON, INC., St. Louis, MO (US)
Filed by MediBeacon Inc., St. Louis, MO (US)
Filed on Aug. 27, 2019, as Appl. No. 16/552,609.
Claims priority of provisional application 62/778,334, filed on Dec. 12, 2018.
Prior Publication US 2020/0187838 A1, Jun. 18, 2020
Int. Cl. A61B 5/1455 (2006.01); A61B 5/00 (2006.01); A61B 5/145 (2006.01); A61K 49/00 (2006.01)
CPC A61B 5/14556 (2013.01) [A61B 5/14525 (2013.01); A61B 5/4848 (2013.01); A61K 49/0021 (2013.01)] 14 Claims
 
1. A method for determining a dosing prescription for a medicament in a patient undergoing continuous renal replacement therapy (CRRT), the method comprising:
administering to the bloodstream of the patient a fluorescent agent, wherein the fluorescent agent is a compound of Formula I

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt thereof;
administering to the patient at least one dose of the medicament wherein administering the fluorescent agent and the medicament to the patient is either sequential or simultaneous;
performing CRRT on the patient after administering the fluorescent agent to the patient;
exposing the fluorescent agent to visible or infrared light, thereby causing spectral energy to emanate from the fluorescent agent;
monitoring transcutaneously a change in the spectral energy from the fluorescent agent over a period of time;
correlating a change in intensity of the spectral energy from the fluorescent agent to a clearance rate of the fluorescent agent from the bloodstream in the patient;
correlating a clearance rate of the medicament in the patient to the clearance rate of the fluorescent agent;
determining a concentration of the medicament in the bloodstream of the patient as a function of time based on the clearance rate of the fluorescent agent; and
adjusting the dosing prescription of the medicament to the patient based on the concentration of the medicament in the bloodstream of the patient as a function of time thereby determining the dosing prescription for the medicament to the patient.