loading a clip on an applicator by coupling a control member of the applicator to clip arms of the clip and by advancing a bushing distally relative to a proximal end of a capsule of the clip so that a plurality of connecting tabs at the proximal end of the capsule slide along a first ramped surface of the bushing until an engaging feature extending radially inward from a first connecting tab of the connecting tabs engages a corresponding engaging feature of the bushing;

inserting the loaded clip to a target site within a living body via a working channel of an endoscope;

moving the control member distally relative to the capsule to move the clip to an open configuration in which distal ends of the clip arms extend out of the capsule and are separated from one another;

positioning the clip adjacent to a target portion of tissue to be clipped;

moving the control member proximally relative to the capsule to move the clip to a closed configuration in which proximal ends of the clip arms are drawn proximally into the capsule to draw the distal ends of the clip arms toward one another to grip the target portion of tissue;

locking the clip arms relative to the capsule in the closed configuration; and

separating the clip from the applicator by drawing the control member proximally relative to the capsule until the connecting tabs slide proximally along a second ramped surface of the bushing plastically deforming each of the connecting tabs from an initial configuration toward a deployed configuration in which each of the engaging features of the connecting tabs is plastically deformed and bent against the connecting tab from which it extends and the first connecting tab is moved away from a longitudinal axis of the capsule to release the bushing from the capsule.