US 12,102,092 B2
Compositions and methods for mitigating pest infestation
Dror Shalitin, Raanana (IL); Noam Grimberg, Kibbutz Lehavot Haviva (IL); and Nir Mogilner, Kibbutz Hatzor-Ashdod (IL)
Assigned to PLANTARCBIO LTD., Raanana (IL); and MERHAV AGRO LTD., Givat Brenner (IL)
Filed by PLANTARCBIO LTD., Raanana (IL); and MERHAV AGRO LTD., Givat Brenner (IL)
Filed on Jun. 9, 2023, as Appl. No. 18/332,614.
Application 18/332,614 is a continuation of application No. 17/260,194, granted, now 11,716,996, previously published as PCT/IL2019/050804, filed on Jul. 17, 2019.
Claims priority of provisional application 62/699,853, filed on Jul. 18, 2018.
Prior Publication US 2023/0301309 A1, Sep. 28, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. C12N 15/82 (2006.01); A01N 63/60 (2020.01); C12N 15/113 (2010.01)
CPC A01N 63/60 (2020.01) [C12N 15/113 (2013.01); C12N 15/8218 (2013.01); C12N 15/8286 (2013.01); C12N 2310/14 (2013.01)] 14 Claims
 
1. A dsRNA for controlling infestation of a plant with an insect, the dsRNA comprising a polynucleotide sequence comprising at least 140 bp and being about 85% to about 100% complementary to a segment of a target gene of the insect, wherein the target gene is a proteasomal beta-subunit gene having the coding sequence as set forth in SEQ ID NO: 3 or SEQ ID NO: 317; and wherein when the dsRNA is topically applied or injected into plants and the plant is ingested by said insect, mortality and/or stunting of said insect is instigated.