CPC G01N 33/5091 (2013.01) [C07K 16/18 (2013.01); G01N 33/563 (2013.01); G01N 2800/367 (2013.01)] | 25 Claims |
1. A method of treating a human or non-human male-female reproductive pair in which the male has low fertility comprising:
subjecting a female human or non-human animal in said human or non-human male-female reproductive pair to artificial insemination or in vitro fertilization; and/or
subjecting a male human or non-human animal in said human or non-human male-female reproductive pair to an effective treatment to increase fertility,
wherein the male was determined to have low fertility comprising a method of detecting total content of Vimentin variant 3 (Vim3) per spermatozoon or spatial localization of Vim3 within spermatozoa in a sperm sample S obtained from the male, wherein one or more of the following conditions are met:
total content of Vim3 per spermatozoon was decreased compared to a fertile control;
total content of Vim3 per spermatozoon was not higher than that of an infertile control;
Vim3 accumulation in the mid pieces of the spermatozoa was decreased compared to a fertile control; or
Vim3 accumulation in the mid piece of the spermatozoa was not higher than an infertile control.
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