CPC G01N 21/658 (2013.01) [C12N 9/1252 (2013.01); C12Q 1/6869 (2013.01); G01N 27/44786 (2013.01); B82Y 30/00 (2013.01)] | 20 Claims |
1. A method of sequencing a DNA strand, comprising:
passing the DNA strand through a nanochannel hot spot of a Raman sensor bounded by plasmonic nanostructures and excited by at least one laser;
identifying the nucleotides of a first section of the DNA strand present in the nanochannel at a first period in time by a Raman signature, and identifying the nucleotides of a second section of the DNA strand present in the nanochannel at a second period in time by a second Raman signature; and
comparing the identified nucleotides of the first section to the identified nucleotides of the second section to identify a change.
|