CPC C12N 15/113 (2013.01) [C12N 2310/14 (2013.01); C12N 2320/11 (2013.01)] | 20 Claims |
1. A nucleic acid comprising an oligonucleotide strand of up to 80 nucleotides in length, wherein said oligonucleotide strand is complementary to a target C5 mRNA sequence set forth as SEQ ID NO: 1262 along at least 21 consecutive nucleotides of said oligonucleotide strand length to reduce C5 target mRNA expression when said nucleic acid is introduced into a mammalian cell, wherein said dsNA comprises a modified nucleotide.
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