CPC C07K 16/44 (2013.01) [C07D 487/04 (2013.01); A61K 2039/505 (2013.01); C07K 2317/21 (2013.01); C07K 2317/24 (2013.01); C07K 2317/54 (2013.01); C07K 2317/55 (2013.01); C07K 2317/565 (2013.01); C07K 2317/569 (2013.01); C07K 2317/622 (2013.01); C07K 2317/626 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01); C07K 2317/94 (2013.01)] | 15 Claims |
1. An antibody or a fragment thereof that specifically binds a cyclopentyltriazolopyrimidine compound of the Formula (Ia):
![]() wherein
R1 is selected from the group consisting of C1-C6 alkoxy and C1-C6 alkylthio;
R2 is selected from the group consisting of H, C1-C6 alkyl, substituted C1-C6 alkyl, C3-C6 cycloalkyl, and substituted C3-C6 cycloalkyl; and
R3 is selected from the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy, and C1-C6 alkanol;
wherein the antibody or a fragment thereof comprises the complementarity-determining regions (CDR) of:
SEQ ID NO:73 (VH CDR1), SEQ ID NO:74 (VH CDR2), SEQ ID NO:75 (VH CDR3), SEQ ID NO:78 (VL CDR1), SEQ ID NO:79 (VL CDR2), and SEQ ID NO:80 (VL CDR3).
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