CPC C07K 16/244 (2013.01) [A61P 37/06 (2018.01); A61K 2039/505 (2013.01); C07K 2317/22 (2013.01); C07K 2317/24 (2013.01); C07K 2317/31 (2013.01); C07K 2317/33 (2013.01); C07K 2317/34 (2013.01); C07K 2317/569 (2013.01); C07K 2317/64 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01); C07K 2317/94 (2013.01); C07K 2319/00 (2013.01)] | 15 Claims |
1. A polypeptide comprising an immunoglobulin single variable domain (ISV), wherein the ISV comprises:
a) a CDR1 which comprises the amino acid sequence of AMG (SEQ ID NO: 238),
b) a CDR2 which has either
(i) the amino acid sequence of AISGSGDDTYYADSVKG (SEQ ID NO: 380), or
(ii) an amino acid sequence that has up to three amino acid differences within the amino acid sequence of AISGSGDDTYYADSVKG (SEQ ID NO: 380); and
c) a CDR3 which has either
(i) the amino acid sequence of RRGLYYVWDSNDYEN (SEQ ID NO: 522), or
(ii) an amino acid sequence that has up to three amino acid differences within the amino acid sequence of RRGLYYVWDSNDYEN (SEQ ID NO: 522)
wherein the immunoglobulin single variable domain binds at least to human IL-17A.
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