US 11,773,159 B2
Polypeptides that bind to IL-17A, IL-17F and/or IL17-A/F and methods of treatment using same
Heidi Rommelaere, Ghent (BE); Joost Alexander Kolkman, Sint-Martens-Latem (BE); Michael John Scott Saunders, Brussels (BE); Ann Union, Aalter (BE); Yolande Chvatchko, Confignon (CH); Amanda E. I. Proudfoot, Chens sur Leman (FR); Alain Vicari, Neydens (FR); Denis Bruniquel, Thoiry (FR); Laurent Chevalet, Cuvat (FR); and Olivier Leger, Saint-Sixt (FR)
Assigned to Merck Patent GmbH, Darmstadt (DE)
Filed by Merck Patent GmbH, Darmstadt (DE)
Filed on Sep. 29, 2020, as Appl. No. 17/36,602.
Application 17/036,602 is a division of application No. 16/002,135, filed on Jun. 7, 2018, granted, now 10,829,552.
Application 16/002,135 is a division of application No. 14/115,549, granted, now 10,017,568, previously published as PCT/EP2012/058313, filed on May 4, 2012.
Claims priority of provisional application 61/482,802, filed on May 5, 2011.
Prior Publication US 2021/0130452 A1, May 6, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 39/395 (2006.01); C07K 16/24 (2006.01); A61P 37/06 (2006.01); A61K 39/00 (2006.01)
CPC C07K 16/244 (2013.01) [A61P 37/06 (2018.01); A61K 2039/505 (2013.01); C07K 2317/22 (2013.01); C07K 2317/24 (2013.01); C07K 2317/31 (2013.01); C07K 2317/33 (2013.01); C07K 2317/34 (2013.01); C07K 2317/569 (2013.01); C07K 2317/64 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01); C07K 2317/94 (2013.01); C07K 2319/00 (2013.01)] 15 Claims
 
1. A polypeptide comprising an immunoglobulin single variable domain (ISV), wherein the ISV comprises:
a) a CDR1 which comprises the amino acid sequence of AMG (SEQ ID NO: 238),
b) a CDR2 which has either
(i) the amino acid sequence of AISGSGDDTYYADSVKG (SEQ ID NO: 380), or
(ii) an amino acid sequence that has up to three amino acid differences within the amino acid sequence of AISGSGDDTYYADSVKG (SEQ ID NO: 380); and
c) a CDR3 which has either
(i) the amino acid sequence of RRGLYYVWDSNDYEN (SEQ ID NO: 522), or
(ii) an amino acid sequence that has up to three amino acid differences within the amino acid sequence of RRGLYYVWDSNDYEN (SEQ ID NO: 522)
wherein the immunoglobulin single variable domain binds at least to human IL-17A.