CPC C07K 14/075 (2013.01) [A61K 31/7088 (2013.01); A61K 35/761 (2013.01); A61K 39/235 (2013.01); C07K 14/5425 (2013.01); C12N 15/861 (2013.01)] | 26 Claims |
1. A recombinant adenovirus comprising:
(I) a nucleotide sequence encoding a hexon protein, wherein:
(a) the nucleotide sequence encoding the hexon protein has at least 93% sequence identity over the entire sequence of SEQ ID NO: 56; or
(b) the hexon protein comprises 99% or greater sequence identity over the entire amino acid sequence of SEQ ID NO: 160;
(II) a nucleotide sequence encoding a short fiber protein, a long fiber protein, and/or a penton protein, wherein:
(a) the nucleotide sequence encoding the short fiber protein has at least 85% identity to the nucleotide sequence of SEQ ID NO: 19;
(b) the short fiber protein has at least 85% identity to the amino acid sequence of SEQ ID NO: 123;
(c) the nucleotide sequence encoding the long fiber protein has at least 90% identity to the nucleotide sequence of SEQ ID NO: 42;
(d) the long fiber protein has at least 90% identity to the amino acid sequence of SEQ ID NO: 146;
(e) the nucleotide sequence encoding the penton protein has at least 95% sequence identity over the entire sequence of SEQ ID NO: 108, and/or
(f) the penton protein comprises 96% or greater sequence identity over the entire amino acid sequence of SEQ ID NO: 212; and
(III) a deletion in or of the E1, E2, and/or E3 region.
|