US 11,773,065 B2
Heterocyclic g-protein-coupled receptor 52 (GPR52) agonists
Jia Zhou, Galveston, TX (US); John A. Allen, Galveston, TX (US); Pingyuan Wang, Galveston, TX (US); and Daniel E. Felsing, Galveston, TX (US)
Assigned to Board of Regents, The University of Texas System, Austin, TX (US)
Filed by Board of Regents, The University of Texas System, Austin, TX (US)
Filed on Oct. 12, 2021, as Appl. No. 17/499,299.
Claims priority of provisional application 63/090,519, filed on Oct. 12, 2020.
Prior Publication US 2022/0112164 A1, Apr. 14, 2022
Int. Cl. C07D 213/74 (2006.01); C07D 405/12 (2006.01); C07D 403/14 (2006.01); C07D 401/04 (2006.01); C07D 403/04 (2006.01); C07D 401/12 (2006.01)
CPC C07D 213/74 (2013.01) [C07D 401/04 (2013.01); C07D 401/12 (2013.01); C07D 403/04 (2013.01); C07D 403/14 (2013.01); C07D 405/12 (2013.01)] 4 Claims
 
1. A compound according to Formula I or pharmaceutically acceptable salt thereof, wherein:

OG Complex Work Unit Chemistry
wherein:
R1 is aryl optionally substituted with one or more groups selected independently from: H, alkyl, cycloalkyl, alkenyl, aryl, heteroaryl, benzyl, alkoxy, halogen, cyan, nitro, amino, hydroxyl, CF3 or —OCF3, wherein alkyl is optionally substituted with one or more chosen substituents chosen from: hydroxyl, cyan, amino, or halogen;
X is CH2;
W is CH;
Y is CH;
Z is CH;
Q is

OG Complex Work Unit Chemistry
R2 is H; and
R3 is selected from: H, alkyl, heteroaryl, heterocyclyl, heterocyclyl-alkyl, and hydroxyl-alkyl; and each group is optionally substituted with one or more groups selected independently from: alkyl, cycloalkyl, alkenyl, aryl, heteroaryl, benzyl, alkoxy, halogen, cyan, nitro, amino, hydroxyl, CF3 or —OCF3;
or R2 and R3 together form a 4-12 membered cycloalkyl ring, and the -12 membered cycloalkyl is optionally substituted with one or more groups selected independently from: alkyl, cycloalkyl, alkenyl, aryl, heteroaryl, benzyl, alkoxy, halogen, cyan, nitro, amino, hydroxyl, CF3 or —OCF3;
R4 is independently chosen from H, alkyl, alkoxy, halogen, cyan, amino, A hydroxyl, nitro, CF3 or —OCF3.