CPC C07D 209/14 (2013.01) [C07B 2200/05 (2013.01)] | 7 Claims |
1. A method of synthesising a compound of formula (I′):
or a pharmaceutically acceptable salt thereof, comprising reacting a compound of formula (II):
with LiAlH4 and/or LiAlD4, wherein the compound of formula (II) is made by:
reacting a compound of formula (III)
with two or more coupling agents to produce an activated compound; and
(ii) reacting the activated compound with an amine having the formula R2R3NH or R2R3ND, wherein:
R1′ is independently selected from —R4, —OPR, —OR4, —F, —Cl, —Br and —I;
PR is a protecting group,
n is selected from 0, 1, 2, 3 or 4;
R2 is C(xH)3;
R3 is C(xH)3 or H;
each R4 is independently selected from C1-C4alkyl; and
each xH and yH is independently protium or deuterium,
wherein a ratio of deuterium:protium in a C(xH)3 moiety in the compound of formula (I′) is greater than that found naturally in hydrogen,
or a pharmaceutically acceptable salt thereof.
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