US 11,773,060 B2
Method for synthesis of 9-cis-beta-carotene and formulations thereof
Ehud Gazit, Ramat-Hasharon (IL); Ludmila Buzhansky, Ariel (IL); Michael Ioffe, Holon (IL); and Alon Sayer, Holon (IL)
Assigned to Ramot at Tel-Aviv University Ltd., Tel Aviv (IL)
Filed by Ramot at Tel-Aviv University Ltd., Tel Aviv (IL)
Filed on Oct. 11, 2021, as Appl. No. 17/450,543.
Application 17/450,543 is a division of application No. 16/303,604, granted, now 11,142,496, previously published as PCT/IL2017/050565, filed on May 21, 2017.
Claims priority of application No. 245847 (IL), filed on May 25, 2016.
Prior Publication US 2022/0098149 A1, Mar. 31, 2022
Int. Cl. C07C 403/24 (2006.01); A61K 9/00 (2006.01); A61K 47/10 (2017.01); A61K 47/14 (2017.01); A61K 31/015 (2006.01); A61K 47/24 (2006.01); A61K 47/44 (2017.01); C07C 45/60 (2006.01); C07C 67/44 (2006.01); C07C 403/02 (2006.01); C07C 403/00 (2006.01)
CPC C07C 403/24 (2013.01) [A61K 9/0053 (2013.01); A61K 31/015 (2013.01); A61K 47/10 (2013.01); A61K 47/14 (2013.01); A61K 47/24 (2013.01); A61K 47/44 (2013.01); C07C 45/60 (2013.01); C07C 67/44 (2013.01); C07C 403/00 (2013.01); C07C 403/02 (2013.01); C07C 2601/16 (2017.05)] 21 Claims
 
1. A formulation comprising an active agent, a thickening/solidifying agent, and an antioxidant, wherein said active agent is 9-cis-β-carotene (9CBC) or a derivative thereof of the formula C:

OG Complex Work Unit Chemistry
wherein R2 is H or methyl; X is

OG Complex Work Unit Chemistry
optionally substituted with one or more methyl groups; n is an integer of 0-16; and the asterisk represents the point of attachment to the cyclohexene ring.