	US 11,772,126 B2
	Systems and methods for delivering therapeutic agents
Apoorva Shah, Burlington, MA (US); Liam O'Neill, Midleton (IE); Patrick Burt, Palo Alto, CA (US); and John O'Donoghue, County Waterford (IE)
Assigned to THERADEP TECHNOLOGIES INC., Palo Alto, CA (US)
Appl. No. 16/74,365
Filed by TheraDep Technologies, Inc., Palo Alto, CA (US)
PCT Filed Jan. 31, 2017, PCT No. PCT/US2017/015805 § 371(c)(1), (2) Date Jul. 31, 2018, PCT Pub. No. WO2017/136334, PCT Pub. Date Aug. 10, 2017.
Claims priority of provisional application 62/289,545, filed on Feb. 1, 2016.
Prior Publication US 2021/0187545 A1, Jun. 24, 2021
Int. Cl. B05D 1/00 (2006.01); A61B 18/04 (2006.01); A61L 27/28 (2006.01); A61L 27/54 (2006.01); A61L 29/08 (2006.01); A61L 29/16 (2006.01); A61L 31/08 (2006.01); A61L 31/16 (2006.01); A61N 1/44 (2006.01); B01L 3/00 (2006.01); B05D 3/02 (2006.01); B05D 3/14 (2006.01); B05D 7/00 (2006.01); A61B 18/00 (2006.01)

CPC B05D 1/62 (2013.01) [A61B 18/042 (2013.01); A61L 27/28 (2013.01); A61L 27/54 (2013.01); A61L 29/08 (2013.01); A61L 29/16 (2013.01); A61L 31/08 (2013.01); A61L 31/16 (2013.01); A61N 1/44 (2013.01); B01L 3/5085 (2013.01); B05D 3/0254 (2013.01); B05D 3/145 (2013.01); B05D 7/54 (2013.01); A61B 2018/00589 (2013.01); A61L 2420/02 (2013.01); B01L 2200/12 (2013.01)]

20 Claims

1. A method of producing a coated substrate, comprising:

introducing a plurality of dry particles as a dry powder into a non-thermal plasma, each particle comprising at least one active agent chosen from biomolecules, pharmaceutical agents, or combinations thereof, wherein the powder does not include hydroxyapatite, calcium phosphates, or other biominerals, the powder having a melting point of less than 100° C.; and

exposing a substrate to the plurality of dry particles and the plasma to deposit a continuous, dry coating comprising the at least one active agent onto the substrate in the absence of polymers, binders, linkers, and excipients.