CPC B01J 13/14 (2013.01) [A61K 9/5021 (2013.01); A61K 9/5073 (2013.01); A61K 9/5089 (2013.01); A61K 9/5138 (2013.01); B01J 13/22 (2013.01); B01L 3/50273 (2013.01); B01L 2200/148 (2013.01)] | 5 Claims |
1. Cell mimicking microparticles (CMMPs) consisting of the following:
1. hyper compliant polymer particles (HCPPs) consisting of synthetic materials cross-linked with a cross-linker and having a mechanical compliance from 0.01 kPa to less than 10 kPa, the synthetic materials selected from the group consisting of a polyacrylamide, a poly(N-vinyl formamide), a polyethylene oxide, a dendrimer, a star polymer, a bioerodible polymer, a polydimethyl siloxane (PDMS), and a combination thereof;
wherein the HCPPs comprise a predetermined size with a monodisperse diameter within a range of about 5 μm to about 40 μm, and including such that the HCPPs are each operative to encapsulate an agent; and,
2. a coating on each of the HCPPs, with said coating including at least one material selected from the group consisting of a protein, a nucleotide sequence, a carbohydrate, a lipid, a cell plasma membrane, a therapeutic agent, a dye targeting agent, and a combination thereof;
wherein the coating extends to the entirety of each of the HCPPs, and each HCPP is thereby entirely encased by coating.
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