US 11,771,916 B2
Interstitial photodynamic therapy
Karl Beeson, Princeton, NJ (US); Evgueni Parilov, Brooklyn, NY (US); and Mary Potasek, Princeton, NJ (US)
Assigned to SIMPHOTEK, INC., Newark, NJ (US)
Appl. No. 18/41,079
Filed by Simphotek, Inc., Newark, NJ (US)
PCT Filed Aug. 10, 2021, PCT No. PCT/US2021/045341
§ 371(c)(1), (2) Date Feb. 9, 2023,
PCT Pub. No. WO2022/039973, PCT Pub. Date Feb. 24, 2022.
Claims priority of provisional application 63/066,895, filed on Aug. 18, 2020.
Prior Publication US 2023/0238099 A1, Jul. 27, 2023
Int. Cl. A61N 5/06 (2006.01); G16H 20/10 (2018.01); A61N 5/067 (2006.01)
CPC G16H 20/10 (2018.01) [A61N 5/0601 (2013.01); A61N 5/062 (2013.01); A61N 5/067 (2021.08); A61N 2005/063 (2013.01); A61N 2005/0626 (2013.01); A61N 2005/0651 (2013.01)] 12 Claims
OG exemplary drawing
 
1. A method of administering interstitial photodynamic therapy by delivering treatment dose to a target region of a patient, the method comprising:
receiving, at a processor, information associated with the target region, an initial photosensitizer concentration, a plurality of initial photosensitizer photokinetic rate parameters, and a threshold treatment dose for a photosensitizer, the threshold treatment dose being a threshold photodynamic therapy-dose or a threshold reactive oxygen species dose;
determining a location in the target region for inserting at least one interstitial treatment fiber to deliver the treatment light;
determining, by the processor, initial values for therapeutic light power, and light emitting length and therapeutic treatment time for the at least one interstitial treatment fiber; determining, by the processor, computational spatial elements for the target region and for the location of emitting surfaces of the at least one interstitial treatment fiber, and a fluence rate for delivering treatment light to each of the computational spatial elements;
determining, by the processor, a treatment dose based on the fluence rate, the plurality of photosensitizer photokinetic rate parameters, and a photokinetic rate equation;
determining, by the processor, a value of one or both of a portion of interior volume and a portion of a boundary region of the target region to which the delivered treatment dose is greater than the threshold treatment dose; and
generating, by the processor, a command for controlling a treatment light source to deliver the treatment dose to the target region via the at least one interstitial treatment fiber.