US 11,771,829 B2
Systems and methods for liquid injection
Robert S. Langer, Newton, MA (US); Carlo Giovanni Traverso, Newton, MA (US); Alex G. Abramson, St. Louis, MO (US); Morten Revsgaard Frederiksen, Copenhagen (DK); Mikkel Oliver Jespersen, Bagsværd (DK); Brian Mouridsen, Bagsbærd (DK); Jesper Windum, Hilleroed (DK); Mette Poulsen, Bagsværd (DK); Brian Jensen, Brønshøj (DK); Jorrit Jeroen Water, Frederiksberg (DK); Mikkel Wennemoes Hvitfeld Ley, Bagsværd (DK); Xiaoya Lu, Toronto (CA); and Andreas Vegge, Frederiksberg (DK)
Assigned to Massachusetts Institute of Technology, Cambridge, MA (US); Novo Nordisk A/S, Bagsvaerd (DK); and The Brigham and Women's Hospital, Inc., Boston, MA (US)
Filed by Massachusetts Institute of Technology, Cambridge, MA (US); The Brigham and Women's Hospital, Inc., Boston, MA (US); and Novo Nordisk A/S, Bagsværd (DK)
Filed on Jan. 31, 2020, as Appl. No. 16/778,152.
Claims priority of provisional application 62/799,882, filed on Feb. 1, 2019.
Prior Publication US 2020/0246545 A1, Aug. 6, 2020
Int. Cl. A61M 5/20 (2006.01); A61K 9/00 (2006.01); A61M 5/30 (2006.01)
CPC A61M 5/2033 (2013.01) [A61K 9/0024 (2013.01); A61M 5/30 (2013.01); A61M 2005/202 (2013.01); A61M 2202/0007 (2013.01); A61M 2202/30 (2013.01); A61M 2210/1042 (2013.01)] 32 Claims
OG exemplary drawing
 
1. A self-righting article, comprising:
a self-actuating component comprising a spring and a support material adapted to maintain the spring in at least a partially compressed state, wherein the support material is configured for at least partial degradation in a biological fluid;
a chamber comprising a liquid active pharmaceutical agent (or non-active to serve as contrast or cushion); and
a tissue interfacing component operably linked to the self-actuating component, the tissue interfacing component comprising an inlet, an outlet, and a channel fluidically connected to the inlet and the outlet;
wherein the chamber is configured to be in fluidic communication with the inlet upon activation of the self-actuating component, and
wherein when the self-righting article is at least partially supported by the tissue of the subject, the self-righting article orients in a direction to allow the tissue interfacing component to release at least a portion of the active pharmaceutical agent into the tissue.