CPC A61K 38/51 (2013.01) [A61K 9/0019 (2013.01); A61K 31/198 (2013.01); A61K 31/205 (2013.01); A61K 31/385 (2013.01); A61K 45/06 (2013.01); A61K 47/60 (2017.08); C12N 9/88 (2013.01); C12N 9/96 (2013.01); C12Y 402/01022 (2013.01); A61K 2300/00 (2013.01)] | 18 Claims |
1. A method of treating homocystinuria in a human subject comprising administering an isolated human truncated cystathionine beta synthase (htCBS) mutant polypeptide, wherein:
(a) the isolated htCBS mutant polypeptide comprises amino acids 2-413 of the amino acid sequence of SEQ ID NO: 13 and has been PEGylated with an ME-200GS PEG molecule, and
(b) the isolated htCBS mutant polypeptide is administered in a dose between 0.33 mg/kg and 10 mg/kg at least once a week for at least six weeks.
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