CPC A61K 38/15 (2013.01) [A61P 33/00 (2018.01); C07D 273/00 (2013.01); C07D 413/10 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01)] | 13 Claims |
1. A compound of Formula (3A)
![]() wherein Ring A and Ring B are the same and are selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, oxetanyl, azetidinyl, piperidinyl, pyrrolidinyl, morpholinyl, tetrahydropyranyl, tetrahydropyrimidinyl, tetrahydropyridinyl, tetrahydropyranyl, thiophenyl, furanyl, thiazolyl, oxazolyl, pyrrolyl, pyrazolyl, imidazolyl, pyridinyl, thiadiazolyl, isothiazolyl, triazinyl, pyrimidinyl, pyrazinyl, pyridazinyl, isoxazolyl, tetrazolyl, oxadiazolyl, 1,2-dihydropyridinyl, triazolyl, quinolinyl, isoquinolinyl, benzofuranyl, 2,3-dihydrothieno[3,4-b][1,4]dioxine, 3,4-dihydro-2H-pyrano[2,3-b]pyridinyl, oxazolo[5,4-b]pyridinyl, pyrazolo[1,5-a]pyridinyl, pyrazolo[1,5-a]pyrimidine, 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridinyl, 4,5-tetrahydropyrazolo[1,5-a]pyrimidine, 1H-pyrrolo[3,2-b]pyridinyl, indazolyl, furo[2,3-b]pyridinyl, and benzo[d][1,3]dioxole; each (R)n is the same and each R in (R)n is independently selected from the group consisting of C1-C6alkyl optionally substituted with at least one substituent selected from hydroxyl, C3-C6cycloalkyl and —ORa; halo, oxo, cyano, hydroxyl, —OR5, —NRaRb, C1-C4haloalkyl, C1-C4haloalkoxy, —S(O)pRa, C1-C6alkoxy, C3-C6cycloalkyl, —C(O)NRaRb, —C(O)Ra, —C(O)ORa, —NRaC(O)Rb, pyrazolyl, imidazolyl, pyridinyl, pyrimidinyl, piperidinyl, morpholinyl, pyrrolidinyl, dihydropyrimidinyl; and phenyl optionally substituted with at least one substituent selected from C1-C3alkyl, —CF3, halo, and hydroxyl; n is 0, 1, 2, or 3;
Ra and Rb are each independently selected from H or C1-C6alkyl;
Rc and Rd are each independently selected from the group consisting of H, hydroxyl, —CF3, F, methyl, ethyl, methoxy, ethoxy and —N(CH2CH3)2; and wherein each Rc is the same and each Rd is the same;
R5 is C3-C6cycloalkyl or C1-C3alkylC3-C6cycloalkyl; and
p is 0, 1, or 2;
stereoisomers thereof, and veterinary acceptable salts thereof.
|