	US 11,771,717 B2
	Applications of pair-production for improved radiotherapy
Derek M. Isrow, Pinecrest, FL (US); Stephen L. Brown, LaSalle (CA); Jae Ho Kim, Irvine, CA (US); Indrin J. Chetty, Canton, MI (US); and Panagiotis Tsiamas, Houston, TX (US)
Assigned to Henry Ford Health System, Detroit, MI (US)
Appl. No. 16/486,367
Filed by Henry Ford Health System, Detroit, MI (US)
PCT Filed Feb. 15, 2018, PCT No. PCT/US2018/018380 § 371(c)(1), (2) Date Aug. 15, 2019, PCT Pub. No. WO2018/152332, PCT Pub. Date Aug. 23, 2018.
Claims priority of provisional application 62/459,283, filed on Feb. 15, 2017.
Prior Publication US 2020/0001111 A1, Jan. 2, 2020
Int. Cl. A61K 33/24 (2019.01); A61P 35/00 (2006.01); A61K 33/243 (2019.01); A61K 31/282 (2006.01); A61K 33/00 (2006.01); A61N 5/10 (2006.01); A61K 33/242 (2019.01)

CPC A61K 33/24 (2013.01) [A61K 31/282 (2013.01); A61K 33/00 (2013.01); A61K 33/242 (2019.01); A61K 33/243 (2019.01); A61N 5/10 (2013.01); A61P 35/00 (2018.01); A61N 2005/1091 (2013.01); A61N 2005/1098 (2013.01)]

7 Claims

1. A method of treating a solid-tumor selected from the group consisting of a Childhood Lung Cancer, a Non-Small Cell Lung Cancer, and a Small Cell Lung Cancer in a patient, wherein the patient is a mammal, comprising the steps of:

a. administering to the patient a pharmaceutically acceptable composition comprising a heavy metal organometallic compound;

b. allowing a time interval of 5 minutes to 12 hours to pass; and

c. irradiating the area of the patient previously identified as the location of the solid tumor with a dose of high energy photons having an energy of 15 MV to 50 MV sufficient to induce positron-electron pair production at the site of the solid tumor.