US 11,771,676 B2
Method for preparing high-load oral paclitaxel capsule for slow release in colon
Yan Hong, Wuxi (CN); Beibei Zhao, Wuxi (CN); Zhengbiao Gu, Wuxi (CN); Li Cheng, Wuxi (CN); Zhaofeng Li, Wuxi (CN); Caiming Li, Wuxi (CN); and Xiaofeng Ban, Wuxi (CN)
Assigned to JIANGNAN UNIVERSITY, Wuxi (CN)
Filed by Jiangnan University, Wuxi (CN)
Filed on Mar. 27, 2023, as Appl. No. 18/190,372.
Application 18/190,372 is a continuation of application No. PCT/CN2022/133867, filed on Nov. 24, 2022.
Claims priority of application No. 202210473997.7 (CN), filed on Apr. 29, 2022.
Prior Publication US 2023/0233511 A1, Jul. 27, 2023
Int. Cl. A61K 31/337 (2006.01); A61K 9/48 (2006.01); A61K 9/50 (2006.01); A61K 9/00 (2006.01)
CPC A61K 31/337 (2013.01) [A61K 9/0053 (2013.01); A61K 9/4866 (2013.01); A61K 9/5036 (2013.01)] 9 Claims
 
1. A method for preparing a high-load oral paclitaxel capsule for slow release in colon, comprising the following steps:
(1) preparing an amorphous paclitaxel:
dripping an ethanol solution of paclitaxel into a water phase, and stirring uniformly and drying the solution to obtain an amorphous paclitaxel microsphere;
(2) adsorbing paclitaxel with porous starch:
redissolving the amorphous paclitaxel microsphere prepared in step (1) in the ethanol solution, dispersing porous starch in the ethanol solution for adsorption, volatilizing a solvent in an oven, washing the porous starch with the ethanol solution to remove unadsorbed paclitaxel, and centrifuging same to obtain a precipitate, namely the porous starch loaded with paclitaxel; and
(3) preparing a chitosan-coated capsule:
dispersing the porous starch loaded with paclitaxel prepared in step (2) in a chitosan solution, after dispersing uniformly to obtain a solution, dropwise adding the solution into a phytic acid solution, and stirring to obtain a coated capsule.