CPC A61K 31/337 (2013.01) [A61K 9/0053 (2013.01); A61K 9/4866 (2013.01); A61K 9/5036 (2013.01)] | 9 Claims |
1. A method for preparing a high-load oral paclitaxel capsule for slow release in colon, comprising the following steps:
(1) preparing an amorphous paclitaxel:
dripping an ethanol solution of paclitaxel into a water phase, and stirring uniformly and drying the solution to obtain an amorphous paclitaxel microsphere;
(2) adsorbing paclitaxel with porous starch:
redissolving the amorphous paclitaxel microsphere prepared in step (1) in the ethanol solution, dispersing porous starch in the ethanol solution for adsorption, volatilizing a solvent in an oven, washing the porous starch with the ethanol solution to remove unadsorbed paclitaxel, and centrifuging same to obtain a precipitate, namely the porous starch loaded with paclitaxel; and
(3) preparing a chitosan-coated capsule:
dispersing the porous starch loaded with paclitaxel prepared in step (2) in a chitosan solution, after dispersing uniformly to obtain a solution, dropwise adding the solution into a phytic acid solution, and stirring to obtain a coated capsule.
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