	US 11,771,648 B2
	Carrier for oromucosal administration of physiologically active substances
Denisa Stranska, Liberec (CZ); Adela Klabanova, Jablonec nad Nisou (CZ); Pavel Dolezal, Hradec Kralove (CZ); Petr Vrbata, Studenka (CZ); Pavel Berka, Opava (CZ); and Marie Musilova, Hradec Kralove (CZ)
Assigned to INSTAR TECHNOLOGIES A.S., Liberec III Jerab (CZ)
Filed by INSTAR TECHNOLOGIES A.S., Liberec III-Jerab (CZ)
Filed on May 5, 2020, as Appl. No. 16/867,470.
Application 16/867,470 is a division of application No. 15/712,631, filed on Sep. 22, 2017, abandoned.
Application 15/712,631 is a continuation of application No. 13/979,039, granted, now 9,789,060, issued on Oct. 17, 2017, previously published as PCT/CZ2011/000116, filed on Dec. 12, 2011.
Claims priority of application No. CZ2011-24 (CZ), filed on Jan. 17, 2011.
Prior Publication US 2020/0261353 A1, Aug. 20, 2020
Int. Cl. A61K 9/00 (2006.01); A61K 9/70 (2006.01)

CPC A61K 9/006 (2013.01) [A61K 9/70 (2013.01)]

14 Claims

1. A method for preparing nanofibers by electrospinning, which nanofibers comprise a mixture of polymers, including a polymer suitable as an adhesive to a wall of a mouth cavity and a drug and/or other physiologically active substance, the method comprising:

(i) dissolving or suspending the polymer suitable as an adhesive to a wall of a mouth cavity in a solvent to obtain a solution;

(ii) dissolving or suspending the drug or other physiologically active substance in the solution to obtain a mixture; and

(iii) electrostatic spinning the mixture to obtain two or more layers of nanofibers;

wherein the two or more layers of nanofibers comprise a nanofiber layer characterized by at least a portion of the polymer suitable as an adhesive to a wall of a mouth cavity attached to a polymer layer comprising the drug or other physiologically active substance.