US 11,771,555 B2
Retrievable self-expanding non-thrombogenic low-profile percutaneous atrioventricular valve prosthesis
Vinay Badhwar, Washington, PA (US); Young Jae Chun, Wexford, PA (US); Antonio D'Amore, Pittsburgh, PA (US); David S. Schwartzman, Pittsburgh, PA (US); and William R. Wagner, Gibsonia, PA (US)
Assigned to University of Pittsburgh—Of the Commonwealth System of Higher Education, Pittsburgh, PA (US)
Filed by University of Pittsburgh—Of the Commonwealth System of Higher Education, Pittsburgh, PA (US)
Filed on Jan. 30, 2020, as Appl. No. 16/777,007.
Application 16/777,007 is a continuation of application No. 15/553,811, granted, now 10,583,004, previously published as PCT/US2016/019849, filed on Feb. 26, 2016.
Claims priority of provisional application 62/121,908, filed on Feb. 27, 2015.
Claims priority of provisional application 62/126,040, filed on Feb. 27, 2015.
Prior Publication US 2020/0170791 A1, Jun. 4, 2020
Int. Cl. A61F 2/24 (2006.01); A61N 1/362 (2006.01); A61L 27/14 (2006.01); A61L 27/50 (2006.01); A61M 25/09 (2006.01); A61F 2/95 (2013.01)
CPC A61F 2/2418 (2013.01) [A61F 2/243 (2013.01); A61F 2/2409 (2013.01); A61F 2/2412 (2013.01); A61L 27/14 (2013.01); A61L 27/50 (2013.01); A61M 25/09 (2013.01); A61N 1/3629 (2017.08); A61F 2002/9505 (2013.01); A61F 2210/0019 (2013.01); A61F 2240/001 (2013.01); A61F 2250/001 (2013.01); A61F 2250/0059 (2013.01); A61L 2400/16 (2013.01)] 19 Claims
OG exemplary drawing
 
1. An atrioventricular prosthesis device comprising:
a frame comprising a plurality of flexible elongated members, the frame being configured to transition from a contracted position, where the frame is configured to be disposed within a catheter tube, to a deployed position, where the frame defines a central cavity having a width which substantially conforms to a diameter of a tricuspid and/or mitral valve opening; and
a valve construct mounted to the frame and spanning at least a portion of the central cavity defined by the frame, the valve construct comprising:
an annular portion defining an aperture connected to at least one of the plurality of elongated members, and
a plurality of leaflets extending longitudinally and radially inwardly from the annular portion, wherein each of the plurality of leaflets comprises a central region that is at least 60% anisotropic comprising a plurality of electrospun synthetic polymer fibers deposited predominantly in a circumferential direction in the central region of each of the plurality of leaflets and a commissure region that is at least 60% anisotropic comprising a plurality of electrospun synthetic polymer fibers deposited predominantly in an axial direction in the commissure region of each of the plurality of leaflets.