CPC A61F 2/2418 (2013.01) [A61F 2/243 (2013.01); A61F 2/2409 (2013.01); A61F 2/2412 (2013.01); A61L 27/14 (2013.01); A61L 27/50 (2013.01); A61M 25/09 (2013.01); A61N 1/3629 (2017.08); A61F 2002/9505 (2013.01); A61F 2210/0019 (2013.01); A61F 2240/001 (2013.01); A61F 2250/001 (2013.01); A61F 2250/0059 (2013.01); A61L 2400/16 (2013.01)] | 19 Claims |
1. An atrioventricular prosthesis device comprising:
a frame comprising a plurality of flexible elongated members, the frame being configured to transition from a contracted position, where the frame is configured to be disposed within a catheter tube, to a deployed position, where the frame defines a central cavity having a width which substantially conforms to a diameter of a tricuspid and/or mitral valve opening; and
a valve construct mounted to the frame and spanning at least a portion of the central cavity defined by the frame, the valve construct comprising:
an annular portion defining an aperture connected to at least one of the plurality of elongated members, and
a plurality of leaflets extending longitudinally and radially inwardly from the annular portion, wherein each of the plurality of leaflets comprises a central region that is at least 60% anisotropic comprising a plurality of electrospun synthetic polymer fibers deposited predominantly in a circumferential direction in the central region of each of the plurality of leaflets and a commissure region that is at least 60% anisotropic comprising a plurality of electrospun synthetic polymer fibers deposited predominantly in an axial direction in the commissure region of each of the plurality of leaflets.
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