US 11,771,325 B2
Multispectral synchronized imaging
Ze Shan Yao, Toronto (CA); Piotr Kuchnio, Toronto (CA); Michael Frank Gunter Wood, Toronto (CA); Tammy Kee-Wai Lee, Toronto (CA); Yanhui Bai, Toronto (CA); Michael Peter Bulk, Toronto (CA); and Christopher Thomas Jamieson, Toronto (CA)
Assigned to Synaptive Medical Inc.
Filed by SYNAPTIVE MEDICAL INC., Toronto (CA)
Filed on Apr. 21, 2021, as Appl. No. 17/301,997.
Application 17/301,997 is a continuation of application No. 15/504,057, granted, now 11,013,414, previously published as PCT/IB2016/052678, filed on May 10, 2016.
Prior Publication US 2021/0235991 A1, Aug. 5, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 5/00 (2006.01); A61B 34/20 (2016.01); A61B 5/026 (2006.01); G01J 3/443 (2006.01); A61B 90/00 (2016.01); A61B 5/06 (2006.01); G01J 3/28 (2006.01); G01J 3/10 (2006.01); G01J 3/02 (2006.01); A61B 90/20 (2016.01); A61B 90/30 (2016.01); A61B 17/34 (2006.01)
CPC A61B 5/0075 (2013.01) [A61B 5/0042 (2013.01); A61B 5/0071 (2013.01); A61B 5/0077 (2013.01); A61B 5/0082 (2013.01); A61B 5/0084 (2013.01); A61B 5/026 (2013.01); A61B 5/061 (2013.01); A61B 5/748 (2013.01); A61B 5/7425 (2013.01); A61B 34/20 (2016.02); A61B 90/361 (2016.02); G01J 3/0248 (2013.01); G01J 3/10 (2013.01); G01J 3/2803 (2013.01); G01J 3/2823 (2013.01); G01J 3/443 (2013.01); A61B 5/0261 (2013.01); A61B 5/725 (2013.01); A61B 17/34 (2013.01); A61B 90/20 (2016.02); A61B 2034/2055 (2016.02); A61B 2090/309 (2016.02); A61B 2562/0233 (2013.01); A61B 2562/0242 (2013.01); G01J 2003/106 (2013.01); G01J 2003/2826 (2013.01)] 21 Claims
OG exemplary drawing
 
1. A multispectral synchronized imaging system, the system comprising:
a control unit configured to:
control a multispectral light source to emit, in a sequence, at least one of visible white light, non-visible light, and to emit, simultaneously, at least two of blue light by at least one blue LED, green light by at least one green LED, and red light by at least one red LED;
control the multispectral light source, a filter positioning device, and a first camera in a synchronized alternating manner to acquire at least one first image and at least one second image,
respectively output the at least one first image and the at least one second image to the display device;
enable the multispectral light source to operate in a first mode, whereby diffused non-visible light is emitted;
control the filter positioning device to position the first optical filter, as the selected optical filter, relative to the first camera so as to filter the diffused non-visible light from the first camera while acquiring the at least one first image, whereby the at least one first image from the first camera comprises at least one fluorescence-imaging image;
output the at least one fluorescence-imaging image to the display device;
enable the multispectral light source to operate in a second mode, whereby coherent non-visible light is emitted;
control the filter positioning device to position the second optical filter, as the selected optical filter, relative to the first camera so as to transmit the coherent non-visible light to the first camera while acquiring the at least one second image, whereby the at least one second image comprises functional imaging of blood flow in the tissue;
process the at least one first image and the at least one second image to quantitatively measure blood flow in the tissue sample; and
output the at least one first image and the at least one second image to the display device along with at least one quantitative measurement of the blood flow;
wherein the at least one first image is acquired by the first camera for each illumination of tissue by the multispectral light source with the blue light, the green light, the visible white light, and the non-visible light, while a first optical filter, as a selected optical filter, is positioned by the filter positioning device relative to the first camera, and
wherein the at least one second image is acquired for illumination of the tissue by the multispectral light source with the non-visible light, while a second optical filter, as the selected optical filter, is positioned by the filter positioning device relative to the first camera.