US 12,429,488 B2
Monoclonal antibody against D-dimer and diagnosis agent for detecting D-dimer, crosslinked fibrin and its derivatives containing D-dimer by using the antibody
Jemo Kang, Princeton, NJ (US); and Jin Yang, North Brunswick, NJ (US)
Assigned to PRINCETON BIOMEDITECH CORPORATION, Monmouth Junction, NJ (US)
Filed by PRINCETON BIOMEDITECH CORPORATION, Monmouth Junction, NJ (US)
Filed on Nov. 21, 2022, as Appl. No. 18/057,333.
Application 18/057,333 is a continuation in part of application No. 15/898,509, filed on Feb. 17, 2018, granted, now 11,506,674, issued on Nov. 22, 2022.
Application 15/898,509 is a continuation in part of application No. 14/581,500, filed on Dec. 23, 2014, granted, now 9,897,616, issued on Feb. 20, 2018.
Application 14/581,500 is a continuation of application No. 12/428,321, filed on Apr. 22, 2009, granted, now 8,940,489, issued on Jan. 27, 2015.
Application 12/428,321 is a continuation of application No. 11/997,247, abandoned, previously published as PCT/KR2005/002491, filed on Jul. 29, 2005.
Prior Publication US 2024/0133904 A1, Apr. 25, 2024
Int. Cl. G01N 33/86 (2006.01); C07K 16/18 (2006.01); C07K 16/26 (2006.01); C07K 16/36 (2006.01); G01N 33/53 (2006.01); G01N 33/543 (2006.01)
CPC G01N 33/86 (2013.01) [C07K 16/18 (2013.01); C07K 16/26 (2013.01); C07K 16/36 (2013.01); G01N 33/54388 (2021.08); C07K 2317/32 (2013.01); C07K 2317/92 (2013.01); G01N 33/5302 (2013.01); G01N 2333/75 (2013.01); G01N 2800/224 (2013.01); G01N 2800/226 (2013.01)] 22 Claims
 
1. An immunochemical assay device for detecting one or more targets of interest in a fluid sample, comprising:
a base member, an array disposed on said base member, said array comprising:
a. a reservoir pad having sufficient porosity and volume to receive and contain a fluid sample upon which an assay is to be performed;
b. a wicking membrane disposed distally to said reservoir pad, said wicking membrane having sufficient porosity and volume to absorb a substantial proportion of the sample received in said reservoir pad; and
c. a dye zone impregnated therein one or more of first immunochemical components conjugated to one or more of indicia labels,
d. an assay indicia zone disposed in said wicking membrane, wherein one or more of second immunochemical components are immobilized,
wherein the one or more of first immunochemical components comprise first immunochemical members,
wherein the one or more of second immunochemical components comprise second immunochemical members, and
wherein each of the first immunochemical member of said one or more of first immunochemical components has a respective second immunochemical member in said one or more of second immunochemical components, said first immunochemical and second immunochemical members are capable of binding specifically to the same target of said one or more of targets of interest to form an immuno-complex.