	US 12,427,182 B2
	Topical erythropoietin formulations and methods for improving wound healing with and cosmetic use of the formulations
Saher Hamed, Nazareth Illit (IL)
Assigned to REMEDOR BIOMED LTD., Nazareth Illit (IL)
Filed by Remedor Biomed Ltd., Nazareth Illit (IL)
Filed on Nov. 29, 2021, as Appl. No. 17/537,020.
Application 17/537,020 is a continuation of application No. 15/757,186, granted, now 11,213,569, previously published as PCT/IB2016/055247, filed on Sep. 1, 2016.
Claims priority of provisional application 62/214,618, filed on Sep. 4, 2015.
Prior Publication US 2022/0339252 A1, Oct. 27, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 38/00 (2006.01); A61K 8/04 (2006.01); A61K 8/64 (2006.01); A61K 9/00 (2006.01); A61K 9/06 (2006.01); A61K 38/18 (2006.01); A61K 38/39 (2006.01); A61K 47/10 (2017.01); A61K 47/14 (2017.01); A61K 47/18 (2017.01); A61K 47/32 (2006.01); A61P 17/02 (2006.01); A61Q 19/00 (2006.01); C07K 14/505 (2006.01); C07K 14/78 (2006.01); C07K 14/00 (2006.01)

CPC A61K 38/1816 (2013.01) [A61K 8/042 (2013.01); A61K 8/64 (2013.01); A61K 9/0014 (2013.01); A61K 9/06 (2013.01); A61K 38/39 (2013.01); A61K 47/10 (2013.01); A61K 47/14 (2013.01); A61K 47/18 (2013.01); A61K 47/32 (2013.01); A61P 17/02 (2018.01); A61Q 19/00 (2013.01); A61K 2300/00 (2013.01); C07K 14/00 (2013.01)]

5 Claims

1. A method of treating a wound in a subject comprising administering to the subject a therapeutically effective amount of a composition that induces aquaporin expression;

wherein the composition comprises an erythropoietin protein at a concentration of between 0.01% to 30% (w/w),

fibronectin protein at a concentration of between 0.01% to 50% (w/w),

glycerol at 5% (w/w),

Carbomer 940 at 1% (w/w),

benzyl alcohol at 2% (w/w),

triethanolamine at about 0.9% (w/w),

methylparaben at 0.2% (w/w),

propylparaben at 0.05% (w/w), and

water to 100% (w/w).