US 12,427,151 B2
Compositions and method of treating cancer
Richard L. Gallo, San Diego, CA (US); and Teruaki Nakatsuji, San Diego, CA (US)
Assigned to The Regents of the University of California, Oakland, CA (US)
Filed by The Regents of the University of California, Oakland, CA (US)
Filed on Jan. 18, 2022, as Appl. No. 17/578,130.
Application 17/578,130 is a division of application No. 16/497,430, granted, now 11,260,058, previously published as PCT/US2018/024511, filed on Mar. 27, 2018.
Claims priority of provisional application 62/638,058, filed on Mar. 2, 2018.
Claims priority of provisional application 62/477,370, filed on Mar. 27, 2017.
Prior Publication US 2022/0241288 A1, Aug. 4, 2022
Int. Cl. A61K 31/52 (2006.01); A61K 9/00 (2006.01); A61K 9/06 (2006.01); A61K 35/741 (2015.01); A61K 45/06 (2006.01); A61P 31/00 (2006.01); A61P 35/00 (2006.01); A61F 13/00 (2024.01); A61K 35/00 (2006.01); A61L 15/40 (2006.01); A61L 15/44 (2006.01); A61P 17/16 (2006.01)
CPC A61K 31/52 (2013.01) [A61K 9/0014 (2013.01); A61K 9/06 (2013.01); A61K 35/741 (2013.01); A61P 31/00 (2018.01); A61P 35/00 (2018.01); A61K 45/06 (2013.01)] 15 Claims
 
1. A method for treating or preventing skin damage due to UV radiation comprising contacting the skin with an effective amount of a composition comprising a compound of Formula I(a):

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt thereof, wherein,
N1-N5 are nitrogen atoms;
X1-X2 are carbon atoms;
the R groups attached by a dashed line are present, or are not present if the R group is connected to an atom that is bound to another atom by a double covalent bond;
the bond indicated by both a straight line and a dashed line indicate that the bond may be a single covalent bond or a double covalent bond;
the fused heterocyclic ring system comprises three double bonds with N2 or N3 forming a double bond and with X1, and with N4 or N5 forming a double bond with X2;
R1 is a hydroxyl; and
R2, R3, R4, R5, R6, R7, R8, and R9 are independently a H, D, optionally substituted (C1-C3)-alkyl.