US 12,099,067 B2
Methods and compositions for diagnosis and prognosis of renal injury and renal failure
Joseph Anderberg, Encinitas, CA (US); Paul McPherson, Encinitas, CA (US); Jeff Gray, Solana Beach, CA (US); Kevin Nakamura, Encinitas, CA (US); James Patrick Kampf, San Diego, CA (US); and Thomas Kwan, San Diego, CA (US)
Assigned to Astute Medical, Inc., San Diego, CA (US)
Filed by ASTUTE MEDICAL, INC., San Diego, CA (US)
Filed on Mar. 31, 2022, as Appl. No. 17/710,832.
Application 17/710,832 is a continuation of application No. 15/520,817, granted, now 11,333,671, previously published as PCT/US2015/056462, filed on Oct. 20, 2015.
Claims priority of provisional application 62/066,316, filed on Oct. 20, 2014.
Claims priority of provisional application 62/066,313, filed on Oct. 20, 2014.
Claims priority of provisional application 62/066,310, filed on Oct. 20, 2014.
Prior Publication US 2022/0236286 A1, Jul. 28, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. G01N 33/68 (2006.01)
CPC G01N 33/6863 (2013.01) [G01N 33/6872 (2013.01); G01N 33/6893 (2013.01); G01N 2333/521 (2013.01); G01N 2333/71 (2013.01); G01N 2800/347 (2013.01)] 20 Claims
 
1. A method for evaluating renal status in a subject and treating the subject based on the evaluation, the method comprising:
performing an assay method configured to detect C-C motif chemokine 14 on a body fluid sample obtained from the subject to provide an assay result; and
correlating the assay result to the subject having a current acute kidney injury (AKI) or an increased likelihood of the subject developing a future AKI; and
treating the subject having the current AKI or the increased likelihood of developing a future AKI with a compatible treatment regimen comprising one or more of initiating renal replacement therapy, modifying diuretic administration, or withdrawing delivery of compounds that are known to be damaging to the kidney.