CPC C07K 7/08 (2013.01) [A61K 9/19 (2013.01); A61K 38/00 (2013.01); A61K 47/22 (2013.01); A61K 47/26 (2013.01); A61P 9/10 (2018.01); C07K 2319/10 (2013.01)] | 18 Claims |
1. A pharmaceutically acceptable salt of a peptide, wherein the peptide comprises the amino acid sequence YEKLLDTEI (SEQ ID NO:1) or a functional variant thereof, wherein the functional variant is a variant only having one or more conservative substitutions in YEKLLDTEI (SEQ ID NO:1), wherein the conservative substitution is selected from the group consisting of a substitution between D and E, a substitution among L, V and I, and a substitution between T and S, wherein the peptide or the functional variant thereof is capable of binding to the PSD-95/Discs-large/ZO-1 1/2 domain (PDZ1/2) domain of postsynaptic density 95 protein (PSD-95) and inhibiting the interaction between PSD-95 and N-methyl-D-aspartic acid receptor (NMDAR), and wherein the salt is an acetate.
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