CPC A61K 31/504 (2013.01) [A61K 9/0053 (2013.01); A61K 31/122 (2013.01); A61K 31/167 (2013.01); A61K 31/401 (2013.01); A61K 31/407 (2013.01); A61K 31/4439 (2013.01); A61K 31/47 (2013.01); A61K 31/497 (2013.01); A61K 31/4985 (2013.01); A61P 35/00 (2018.01); A61K 31/4166 (2013.01); A61K 31/58 (2013.01); A61K 2300/00 (2013.01)] | 16 Claims |
1. A compound, or a stereoisomer, pharmaceutically acceptable salt, or ester thereof, selected from:
a compound according to formula III
where the bond represented by “-----” is a single or double bond,
R20 is (a) phenyl substituted with C1-C3 perfluoroalkyl, halo, or pentafluorosulfanyl,
(b) thiophenyl substituted with C1-C3 alkyl, or (c) cycloalkyl substituted with C1-C3 perfluoroalkyl,
R23 is (a) phenyl mono- or di-substituted with substituents selected from halo, C1-C3 alkyl, C1-C3 perfluoroalkyl, pentafluorosulfanyl, cyano, —C(O)Oalkyl, or —C(O)N(H)alkyl, (b) cycloalkyl, or
(c) heterocycloalkyl,
R24 and R25 are absent if the bond represented by “-----” is a double bond, or R24 and R25 independently are hydrogen, deuterium, C1-C3 perhaloalkyl, halo, or cyano, or R24 and R25 together form —CH2—, and
R26 and R27 independently are hydrogen, deuterium, or halo,
wherein if R24-R27 are hydrogen, then R20 is not halo-substituted phenyl, and
if R24-R27 are hydrogen and R23 is phenyl mono- or di-substituted with substituents selected from halo, C1-C3 alkyl, C1-C3 perfluoroalkyl, pentafluorosulfanyl, cyano, —C(O)Oalkyl, or —C(O)N(H)alkyl, then R20 is (a) pentafluorosulfanyl-substituted phenyl, (b) thiophenyl substituted with C1-C3 alkyl, or (c) cycloalkyl substituted with C1-C3 perfluoroalkyl.
|