US 11,766,400 B2
Biodegradable contraceptive implants
W. Mark Saltzman, New Haven, CT (US); Elias Quijano, Durham, CT (US); Fan Yang, Branford, CT (US); Zhaozhong Jiang, New Haven, CT (US); and Derek Owen, Durham, NC (US)
Assigned to YALE UNIVERSITY, New Haven, CT (US); and FAMILY HEALTH INTERNATIONAL, Durham, NC (US)
Appl. No. 16/344,663
Filed by Yale University, New Haven, CT (US); and Family Health International, Durham, NC (US)
PCT Filed Oct. 24, 2017, PCT No. PCT/US2017/058107
§ 371(c)(1), (2) Date Apr. 24, 2019,
PCT Pub. No. WO2018/081138, PCT Pub. Date May 3, 2018.
Claims priority of provisional application 62/411,872, filed on Oct. 24, 2016.
Prior Publication US 2020/0054553 A1, Feb. 20, 2020
Int. Cl. A61K 9/00 (2006.01); A61K 31/567 (2006.01)
CPC A61K 9/0024 (2013.01) [A61K 31/567 (2013.01)] 17 Claims
 
1. A non-injectable biodegradable contraceptive implant for implantation in tissue in a female subject comprising
a contraceptive agent free biodegradable core having a coating thereon, the coating being formed of a biocompatible polyester copolymer,
wherein the biodegradable polyester copolymer is poly(ω-pentadecalactone-co-p-dioxanone) having a general structure according to Formula (I)

OG Complex Work Unit Chemistry
wherein n and m are independently integer values of less than or equal to about 1500, and
having in the coating on the core, but not in the core, an effective amount of a contraceptive agent being released with zero order kinetics to prevent pregnancy in the female subject over a period of twelve to twenty-four months, and
an outer biodegradable poly(ω-pentadecalactone-co-p-dioxanone) coating on the coating on the core, wherein the outer coating does not contain contraceptive agent.