US 12,424,427 B2
Two dimensional MSMS
Keith Richardson, High Peak (GB); and Jason Lee Wildgoose, Stockport (GB)
Assigned to Micromass UK Limited, Wilmslow (GB)
Filed by Micromass UK Limited, Wilmslow (GB)
Filed on Jul. 10, 2024, as Appl. No. 18/768,828.
Application 18/768,828 is a continuation of application No. 18/450,232, filed on Aug. 15, 2023, granted, now 12,062,532.
Application 18/450,232 is a continuation of application No. 17/356,793, filed on Jun. 24, 2021, granted, now 11,769,654.
Application 17/356,793 is a continuation of application No. 16/910,960, filed on Jun. 24, 2020, granted, now 11,075,063, issued on Jul. 27, 2021.
Application 16/910,960 is a continuation of application No. 16/093,443, granted, now 10,727,036, issued on Jul. 28, 2020, previously published as PCT/GB2017/051052, filed on Apr. 13, 2017.
Claims priority of provisional application 62/322,404, filed on Apr. 14, 2016.
Prior Publication US 2024/0363321 A1, Oct. 31, 2024
Int. Cl. H01J 49/00 (2006.01); H01J 49/02 (2006.01)
CPC H01J 49/0031 (2013.01) [H01J 49/0009 (2013.01); H01J 49/004 (2013.01); H01J 49/005 (2013.01); H01J 49/0072 (2013.01); H01J 49/025 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method of mass spectrometry comprising:
performing a plurality of cycles of operation during a single experimental run, wherein each cycle comprises: mass selectively transmitting precursor ions of a single mass, or range of masses, through or out of a mass separator or mass filter at any given time, wherein the mass separator or mass filter is operated such that the single mass or range of masses capable of being transmitted therefrom is varied with time; and
mass analysing ions;
wherein ions transmitted by the mass separator or filter in at least some of said cycles are fragmented or reacted to produce fragment or product ions, and wherein the method comprises varying the fragmentation energy or rate, or reaction energy or rate, during one or more of said cycles, or during said experimental run.