US 12,422,671 B2
Oblique plane microscope and method for correcting an aberration in an oblique plane microscope
Christian Schumann, Lich (DE)
Assigned to LEICA MICROSYSTEMS CMS GMBH, Wetzlar (DE)
Appl. No. 17/788,783
Filed by LEICA MICROSYSTEMS CMS GMBH, Wetzlar (DE)
PCT Filed Jan. 9, 2020, PCT No. PCT/EP2020/050425
§ 371(c)(1), (2) Date Jun. 24, 2022,
PCT Pub. No. WO2021/139889, PCT Pub. Date Jul. 15, 2021.
Prior Publication US 2023/0035107 A1, Feb. 2, 2023
Int. Cl. G02B 27/00 (2006.01); G02B 21/00 (2006.01); G02B 21/02 (2006.01); G02B 21/36 (2006.01); G06T 7/00 (2017.01); H04N 23/69 (2023.01)
CPC G02B 27/0068 (2013.01) [G02B 21/0032 (2013.01); G02B 21/025 (2013.01); G02B 21/367 (2013.01); G06T 7/0002 (2013.01); H04N 23/69 (2023.01); G06T 2207/10056 (2013.01); G06T 2207/30168 (2013.01)] 10 Claims
OG exemplary drawing
 
1. An oblique plane microscope, comprising:
an optical imaging system configured to form an image of an object, the optical imaging system comprising a telescope system with an optical zoom system, which is adjustable for adapting a magnification of the telescope system to a ratio between two refractive indices, one of which being associated with an object side of the telescope system and the other being associated with an image side of the telescope system; and
a control unit,
wherein the telescope system comprises an objective arranged at the object side of the telescope system, wherein the control unit is configured to divide the image formed by the oblique plane microscope into three or more areas, wherein a first area comprises an image of a first region of the object and a second area comprises an image of a second region of the object, wherein the first region is located off of a focal plane of the objective on a first side facing away from the objective, and the second region is located off of the focal plane of the objective on a second side facing the objective, and wherein the control unit is configured to evaluate an image quality only in the first area and/or the second area, and to adjust the optical zoom system based on the evaluation.