US 12,422,570 B2
System and methods for measuring patient-specific extravasation dosimetry
Steven Perrin, Durham, NC (US); Joshua G. Knowland, Cary, NC (US); and William Gorge, Carmel, IN (US)
Assigned to Lucerno Dynamics, LLC, Cary, NC (US)
Filed by Lucerno Dynamics, LLC, Cary, NC (US)
Filed on Jan. 12, 2023, as Appl. No. 18/096,213.
Claims priority of provisional application 63/298,810, filed on Jan. 12, 2022.
Prior Publication US 2023/0243983 A1, Aug. 3, 2023
Int. Cl. A61N 5/10 (2006.01); G01T 1/02 (2006.01); G01T 1/161 (2006.01)
CPC G01T 1/026 (2013.01) [A61N 5/1071 (2013.01); G01T 1/161 (2013.01)] 7 Claims
OG exemplary drawing
 
1. A method of determining patient-specific extravasation dosimetry, comprising:
a. determining a count-rate curve over a time-period of interest using one or more radiation probes positioned proximate a region of interest;
b. determining a calibration factor for converting the count-rate curve to an absolute activity curve, wherein the calibration factor is determined by dividing the count rate at an imaging time by total activity from the region of interest;
c. determine an absorbed energy fraction based on tissue characteristics and the size and location of the region of interest;
d. determine absorbed dose to infiltrated tissue by summing total energy emitted in region of interest based on the count rate curve and calibration factor and absorbed energy fraction.