US 12,421,484 B2
Bioreactor assembly, bioreactor, and method of operating same
Lisa M. Larkin, Ann Arbor, MI (US); Ellen M. Arruda, Ann Arbor, MI (US); Michael J. Smietana, Memphis, TN (US); Pablo Moncado-Larrotiz, San Francisco, CA (US); and Haley Titinger, Ann Arbor, MI (US)
Assigned to The Regents of the University of Michigan, Ann Arbor, MI (US); and STEL TECHNOLOGIES, LLC, Ann Arbor, MI (US)
Appl. No. 17/614,257
Filed by The Regents of the University of Michigan, Ann Arbor, MI (US); and STEL TECHNOLOGIES, LLC, Ann Arbor, MI (US)
PCT Filed May 24, 2020, PCT No. PCT/US2020/034443
§ 371(c)(1), (2) Date Nov. 24, 2021,
PCT Pub. No. WO2020/243035, PCT Pub. Date Dec. 3, 2020.
Claims priority of provisional application 62/852,715, filed on May 24, 2019.
Prior Publication US 2022/0243156 A1, Aug. 4, 2022
Int. Cl. C12M 3/00 (2006.01); C12M 1/00 (2006.01); C12M 1/12 (2006.01); C12M 1/42 (2006.01)
CPC C12M 21/08 (2013.01) [C12M 23/02 (2013.01); C12M 23/22 (2013.01); C12M 25/04 (2013.01); C12M 29/10 (2013.01); C12M 29/20 (2013.01); C12M 35/08 (2013.01)] 14 Claims
OG exemplary drawing
 
1. A bioreactor, comprising:
an external surface;
a first tissue culture side for culturing a first cell source in a first tissue culture support region, wherein the first tissue culture support region includes a first tissue culture support surface that supports two or more separate tissue culture plates, and wherein two media collection reservoirs are situated below the two or more separate tissue culture plates;
a second tissue culture side for culturing a second cell source in a second tissue culture support region, wherein the second tissue culture support region includes a second tissue culture support surface that supports a single tissue culture plate; and
a plurality of ports, wherein at least one of the ports of the plurality of ports extends from the first tissue culture support region of the first tissue culture side to the external surface.