US 12,421,480 B2
Core-shell capsules prepared with linear and cyclic aliphatic polyisocyanates
Patrick Ott, Holzminden (DE); Kolja Behrens, Polle (DE); Timothy J. Evans-Lorra, Brooklyn, NY (US); and John M. Teffenhart, Edison, NJ (US)
Assigned to SYMRISE AG, Holzminden (DE)
Appl. No. 17/049,070
Filed by SYMRISE AG, Holzminden (DE)
PCT Filed Apr. 24, 2018, PCT No. PCT/EP2018/060492
§ 371(c)(1), (2) Date Oct. 20, 2020,
PCT Pub. No. WO2019/206404, PCT Pub. Date Oct. 31, 2019.
Prior Publication US 2021/0238510 A1, Aug. 5, 2021
Int. Cl. C11D 17/00 (2006.01); A61K 8/11 (2006.01); A61Q 13/00 (2006.01); B01J 13/16 (2006.01); C08G 18/32 (2006.01); C08G 18/72 (2006.01); C08G 18/73 (2006.01); C08G 18/75 (2006.01); C11D 3/00 (2006.01); C11D 3/50 (2006.01)
CPC C11D 17/0039 (2013.01) [A61K 8/11 (2013.01); A61Q 13/00 (2013.01); B01J 13/16 (2013.01); C08G 18/3225 (2013.01); C08G 18/722 (2013.01); C08G 18/73 (2013.01); C08G 18/758 (2013.01); C11D 3/001 (2013.01); C11D 3/505 (2013.01); A61K 2800/412 (2013.01); A61K 2800/56 (2013.01)] 15 Claims
 
1. A core-shell capsule comprising a core and a shell,
the shell consisting of a product produced or producible by reacting one or more linear and/or branched aliphatic polyisocyanates having more than one isocyanate group and one or more cyclic aliphatic polyisocyanates having more than one isocyanate group with one or more crosslinking agents, wherein:
the one or more linear and/or branched aliphatic polyisocyanates are selected from the group consisting of pentamethylene diisocyanate, hexamethylene diisocyanate, ethyl ester lysine triisocyanate, lysine diisocyanate ethyl ester, and oligomers and/or adducts thereof, wherein the oligomers are biurets, isocyanurates, uretdiones, or iminooxadiazinediones and the adducts are trimethylol propane adducts, and
the one or more cyclic aliphatic polyisocyanates are selected from the group consisting of 1,3-bis(isocyanatomethyl)cyclohexane, 1,2-bis(isocyanatomethyl)-cyclohexane, 1,4-bis(isocyanatomethyl)cyclohexane, and derivatives thereof.