US 12,421,369 B2
Porous polymer scaffolds, and methods of making and using the same
Tejal A. Desai, San Francisco, CA (US); Ryan Chang, San Francisco, CA (US); and Jasper Z. Williams, San Francisco, CA (US)
Assigned to The Regents of the University of California, Oakland, CA (US)
Appl. No. 16/309,081
Filed by The Regents of the University of California, Oakland, CA (US)
PCT Filed Jun. 13, 2017, PCT No. PCT/US2017/037296
§ 371(c)(1), (2) Date Dec. 11, 2018,
PCT Pub. No. WO2017/218565, PCT Pub. Date Dec. 21, 2017.
Claims priority of provisional application 62/350,003, filed on Jun. 14, 2016.
Prior Publication US 2019/0119462 A1, Apr. 25, 2019
Int. Cl. C08J 9/26 (2006.01); A61L 27/18 (2006.01); A61L 27/24 (2006.01); A61L 27/34 (2006.01); A61L 27/36 (2006.01); A61L 27/38 (2006.01); A61L 27/54 (2006.01); A61L 27/56 (2006.01); B01D 39/16 (2006.01)
CPC C08J 9/26 (2013.01) [A61L 27/18 (2013.01); A61L 27/24 (2013.01); A61L 27/34 (2013.01); A61L 27/3604 (2013.01); A61L 27/3616 (2013.01); A61L 27/3804 (2013.01); A61L 27/3895 (2013.01); A61L 27/54 (2013.01); A61L 27/56 (2013.01); B01D 39/1676 (2013.01); B01D 2239/0407 (2013.01); B01D 2239/1216 (2013.01); C08J 2201/0446 (2013.01); C08J 2205/044 (2013.01); C08J 2205/048 (2013.01); C08J 2205/05 (2013.01); C08J 2207/10 (2013.01); C08J 2367/04 (2013.01)] 15 Claims
 
1. A polycaprolactone (PCL) scaffold consisting of:
a monolithic, continuous structure comprising a plurality of pores, wherein the plurality of pores comprises macropores interconnected by struts containing micropores, wherein the macropores have an average diameter of from 50 μm to 500 μm and the micropores have an average diameter of 20 μm or less; and
wells that are distinct from the plurality of pores and that are arranged on the surface of the scaffold in a honeycomb pattern;
wherein the micropores and macropores are present on external surfaces of the PCL scaffold.