US 12,421,309 B2
Anti-TM4SF4 antibody and uses thereof
In Gyu Kim, Daejeon (KR); Rae Kwon Kim, Sejong (KR); Jai Ha Lee, Daejeon (KR); Chang Kyu Heo, Daejeon (KR); Yeon Jee Kahm, Hwaseong-si (KR); Byung Chul Shin, Seoul (KR); Eun Wie Cho, Daejeon (KR); Chun Jeih Ryu, Seoul (KR); Min Kyu Kim, Seoul (KR); and Mun Ju Choi, Seoul (KR)
Assigned to KOREA ATOMIC ENERGY RESEARCH INSTITUTE, Daejeon (KR)
Appl. No. 17/299,156
Filed by KOREA ATOMIC ENERGY RESEARCH INSTITUTE, Daejeon (KR)
PCT Filed Dec. 4, 2020, PCT No. PCT/KR2020/017699
§ 371(c)(1), (2) Date Jun. 2, 2021,
PCT Pub. No. WO2021/112640, PCT Pub. Date Jun. 10, 2021.
Claims priority of application No. 10-2019-0162068 (KR), filed on Dec. 6, 2019.
Prior Publication US 2023/0002485 A1, Jan. 5, 2023
Int. Cl. C07K 16/28 (2006.01); A61K 39/00 (2006.01); A61P 11/00 (2006.01); A61P 35/00 (2006.01)
CPC C07K 16/28 (2013.01) [A61P 11/00 (2018.01); A61P 35/00 (2018.01); A61K 2039/505 (2013.01); C07K 2317/21 (2013.01); C07K 2317/34 (2013.01); C07K 2317/565 (2013.01); C07K 2317/76 (2013.01)] 17 Claims
 
1. An antibody or antigen-binding fragment thereof that specifically binds to TransMembrane 4 Superfamily Member 4 (TM4SF4), wherein
the antibody binds to an epitope region including an amino acid sequence of SEQ ID NO: 2, wherein the antibody is
(a) an antibody including a heavy chain variable region having CDR-H1 including the amino acid sequence of SEQ ID NO: 3, CDR-H2 including the amino acid sequence of SEQ ID NO: 4, and CDR-H3 including the amino acid sequence of SEQ ID NO: 5; and a light chain variable region having CDR-L1 including the amino acid sequence of SEQ ID NO: 6, CDR-L2 including the amino acid sequence of SEQ ID NO: 7, and CDR-L3 including the amino acid sequence of SEQ ID NO: 8; or
(b) an antibody including a heavy chain variable region having CDR-H1 including the amino acid sequence of SEQ ID NO: 9, CDR-H2 including the amino acid sequence of SEQ ID NO: 10, and CDR-H3 including the amino acid sequence of SEQ ID NO: 11; and a light chain variable region having CDR-L1 including the amino acid sequence of SEQ ID NO: 12, CDR-L2 including the amino acid sequence of SEQ ID NO: 13, and CDR-L3 including the amino acid sequence of SEQ ID NO: 14.