US 12,421,272 B2
Artificial nucleic acid, production method therefor, and use thereof
Ikuya Ban, Ibaraki (JP); Haruhisa Yoshikawa, Ibaraki (JP); Ayako Orita, Ibaraki (JP); and Takeshi Imanishi, Ibaraki (JP)
Assigned to SYSMEX CORPORATION, Kobe (JP)
Filed by SYSMEX CORPORATION, Kobe (JP)
Filed on Sep. 28, 2021, as Appl. No. 17/487,906.
Application 17/487,906 is a continuation in part of application No. PCT/JP2020/014332, filed on Mar. 27, 2020.
Claims priority of application No. 2019-067564 (JP), filed on Mar. 29, 2019.
Prior Publication US 2022/0089634 A1, Mar. 24, 2022
Int. Cl. C07H 19/06 (2006.01); C07H 1/00 (2006.01); C07H 19/16 (2006.01); C07H 21/00 (2006.01); C12Q 1/68 (2018.01); C12Q 1/6844 (2018.01)
CPC C07H 19/06 (2013.01) [C07H 1/00 (2013.01); C07H 19/16 (2013.01); C07H 21/00 (2013.01); C12Q 1/6844 (2013.01)] 14 Claims
 
1. A compound represented by formula (1) or a salt thereof:

OG Complex Work Unit Chemistry
wherein
Base represents an aromatic heterocyclic group which may have a substituent or an aromatic hydrocarbon ring group which may have a substituent;
A1 represents a linear alkylene group;
A2 represents a single bond or an alkylene group;
X represents an alkylene group which may have a substituent or an alkylene group in which at least one methylene group moiety is substituted by —N(RX)— wherein RX represents a hydrogen atom or an alkyl) group, —O— or —S(═O)k— wherein k represents 0, 1, or 2;
R1 and R2 are the same as or different from each other and independently represent a hydrogen atom, an alkyl group which may have a substituent, an alkenyl group which may have a substituent, a cycloalkyl group which may have a substituent, a cycloalkenyl group which may have a substituent, an aryl group which may have a substituent, a protecting group for a hydroxyl group, a phosphino group which has a substituent, a dihydroxyphosphinyl group which may have a substituent, or a hydroxymercaptophosphinyl group which may have a substituent, or R1, R2, two oxygen atoms respectively adjacent to R1 and R2 and carbon atoms at position-3 and position-5 in a furanose together form a ring which may have a substituent; and
R3 represents an amino group which may have a substituent.