US 12,421,248 B2
Macrocyclic compound and uses thereof
Yoshito Kishi, Cambridge, MA (US); Kazunobu Kira, Tsukuba (JP); and Ken Ito, Tsukuba (JP)
Assigned to President and Fellows of Harvard College, Cambridge, MA (US); and Eisai R&D Management Co., Ltd., Tokyo (JP)
Filed by President and Fellows of Harvard College, Cambridge, MA (US); and Eisai R&D Management Co., LTD., Tokyo (JP)
Filed on Jun. 21, 2023, as Appl. No. 18/339,227.
Application 18/339,227 is a continuation of application No. 17/167,480, filed on Feb. 4, 2021, granted, now 11,725,015.
Application 17/167,480 is a continuation of application No. 16/500,924, granted, now 10,954,249, previously published as PCT/US2018/025887, filed on Apr. 3, 2018.
Application 16/500,924 is a continuation of application No. 15/814,105, filed on Nov. 15, 2017, granted, now 9,938,288.
Claims priority of provisional application 62/586,416, filed on Nov. 15, 2017.
Claims priority of provisional application 62/526,677, filed on Jun. 29, 2017.
Claims priority of provisional application 62/482,030, filed on Apr. 5, 2017.
Prior Publication US 2023/0406863 A1, Dec. 21, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 493/22 (2006.01); A61K 31/357 (2006.01); A61K 39/395 (2006.01); A61P 35/00 (2006.01); C07K 16/28 (2006.01); A61K 39/00 (2006.01)
CPC C07D 493/22 (2013.01) [A61K 31/357 (2013.01); A61K 39/3955 (2013.01); A61P 35/00 (2018.01); C07K 16/2818 (2013.01); C07K 16/2863 (2013.01); A61K 2039/505 (2013.01); A61K 2300/00 (2013.01)] 11 Claims
 
1. A method of treating a cancer or tumor in a subject comprising administering to the subject a compound of the following structure:

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt thereof, wherein the cancer or tumor is bladder cancer, gastric cancer, or small bowel cancer.