US 12,421,221 B2
Heterocyclic-substituted pyrimidine derivative exhibiting cancer cell growth inhibitory effect, and pharmaceutical composition containing same
Sung-Eun Kim, Seoul (KR); Sunho Lee, Seoul (KR); Rengasamy Rajesh, Suwon-si (KR); Yong Hyub Lee, Goyang-si (KR); and Sung Tak Hong, Seoul (KR)
Assigned to ONCOBIX CO., LTD., Yongin-si (KR)
Appl. No. 17/601,790
Filed by ONCOBIX CO., LTD., Yongin-si (KR)
PCT Filed Oct. 8, 2020, PCT No. PCT/KR2020/013779
§ 371(c)(1), (2) Date Oct. 6, 2021,
PCT Pub. No. WO2021/085888, PCT Pub. Date May 6, 2021.
Claims priority of application No. 10-2019-0137489 (KR), filed on Oct. 31, 2019.
Prior Publication US 2022/0204492 A1, Jun. 30, 2022
Int. Cl. C07D 413/14 (2006.01); C07D 403/14 (2006.01); C07D 417/14 (2006.01); C07D 487/10 (2006.01); C07D 491/107 (2006.01)
CPC C07D 413/14 (2013.01) [C07D 403/14 (2013.01); C07D 417/14 (2013.01); C07D 487/10 (2013.01); C07D 491/107 (2013.01)] 8 Claims
 
1. A compound of Chemical Formula 1 below or a salt thereof:

OG Complex Work Unit Chemistry
X is oxygen,
R1 is an alkyl group of C1 to C4, or a cycloalkyl group of C3 to C6,
R2 is H or an alkyl group of C1 to C4,
R3 is hydrogen or a halogen group,
R4 is hydrogen, a halogen group, or an alkyl group of C1 to C4, R5 is hydrogen or an alkyl group of C1 to C4,
R6 is hydrogen or an alkyl group of C1 to C4,
R7 is a pyrazolyl group unsubstituted or substituted with a C1 to C4 alkyl group, an imidazolyl group unsubstituted or substituted with a C1 to C4 alkyl group, or a triazolyl group unsubstituted or substituted with a C1 to C4 alkyl group, and
R8 is a morpholinyl group unsubstituted or substituted with a C1 to C4 alkyl group, a thiomorpholinyl group unsubstituted or substituted with a C1 to C4 alkyl group, piperazinyl group unsubstituted or substituted with a C1 to C4 alkyl group, a diazaspiro group of C5 to C10 unsubstituted or substituted with a C1 to C4 alkyl group, an oxoazaspiro group of C5 to C10 unsubstituted or substituted with a C1 to C4 alkyl group, a thioazaspiro group of C5 to C10 unsubstituted or substituted with a C1 to C4 alkyl group, or a N1,N1,N2-tri (C1 to C4 alkyl)ethylene diamine group,
wherein X forms a double bond with S, and S forms a single bond with N.