	US 12,421,210 B2
	Fused bicyclic heterocycles as therapeutic agents
John K. Dickson, Apex, NC (US); Andrew S. Chi, New York, NY (US); Xinyan Huang, Paramus, NJ (US); and Nadim Shohdy, Garden City, NY (US)
Assigned to NEW YORK UNIVERSITY, New York, NY (US)
Appl. No. 17/282,917
Filed by NEW YORK UNIVERSITY, New York, NY (US)
PCT Filed Oct. 5, 2019, PCT No. PCT/US2019/054905 § 371(c)(1), (2) Date Apr. 5, 2021, PCT Pub. No. WO2020/073031, PCT Pub. Date Apr. 9, 2020.
Claims priority of provisional application 62/742,041, filed on Oct. 5, 2018.
Prior Publication US 2021/0395222 A1, Dec. 23, 2021
Int. Cl. C07D 401/14 (2006.01); C07D 209/94 (2006.01); C07D 333/54 (2006.01); C07D 401/12 (2006.01); C07D 403/04 (2006.01); C07D 405/14 (2006.01); C07D 409/12 (2006.01); C07D 413/14 (2006.01); C07D 417/14 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); C07D 491/048 (2006.01); C07D 491/052 (2006.01); C07D 495/04 (2006.01); C07D 498/04 (2006.01); C07D 513/04 (2006.01); C07D 513/14 (2006.01)

CPC C07D 401/14 (2013.01) [C07D 209/94 (2013.01); C07D 401/12 (2013.01); C07D 405/14 (2013.01); C07D 409/12 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); C07D 491/048 (2013.01); C07D 491/052 (2013.01); C07D 495/04 (2013.01); C07D 498/04 (2013.01); C07D 513/04 (2013.01); C07D 513/14 (2013.01)]

10 Claims

1. A compound which is:

tert-butyl 6-(2-((E)-3-(pyridin-3-yl)acrylamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

tert-butyl 6-(2-(2-(pyridin-3-yloxy) acetamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

tert-butyl 6-(2-(thieno [2,3-b]pyridine-2-carboxamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

tert-butyl 6-(2-((E)-3-(6-aminopyridin-3-yl)acrylamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

tert-butyl 6-(2-(furo [2,3-b]pyridine-2-carboxamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

tert-butyl 6-(2-(benzo [b]thiophene-5-carboxamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

tert-butyl 6-(2-(imidazo [1,2-a]pyridine-6-carboxamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

tert-butyl 6-(2-pivalamidoethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

tert-butyl 6-(2-((E)-3-(3-methylisoxazolo [5,4-b]pyridin-5-yl)acrylamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

tert-butyl 6-(2-(2-(pyridin-3-yl)cyclopropanecarbox-amido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

tert-butyl 6-(2-(thiazolo [5,4-c]pyridine-2-carboxamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

tert-butyl 6-(2-(5-(pyridin-3-yl) isoxazole-3-carboxamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

ter-butyl 6-(2-(5-aminothieno [2,3-c]pyridine-2-carboxamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

tert-butyl 6-(2-acetamidoethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

tert-butyl 6-(2-(isoindoline-2-carboxamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

tert-butyl 6-(2-(4,5,6,7-tetrahydrothieno [3,2-c]pyridine-5-carboxamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

tert-butyl 6-(2-(3-(pyridin-3-yl)azetidine-1-carboxamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

tert-butyl 6-(2-((E)-2-cyano-3-(pyridin-4-yl)guanidino)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

tert-butyl 6-(2-(3-((pyridin-3-yl)methyl) ureido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

tert-butyl 6-(2-(2,3-dihydro-1H-pyrrolo [3,4-c]pyridine-2-carboxamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

3-methyloxetan-3-yl 6-(2-((E)-3-(pyridin-3-yl)acrylamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

(E)-N-(2-(3-benzoyl-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(phenylsulfonyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

3-methyloxetan-3-yl 6-(2-((E)-3-(6-aminopyridin-3-yl)acrylamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

(E)-3-(6-aminopyridin-3-yl)-N-(2-(3-benzoyl-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

3-methyloxetan-3-yl 6-(2-(thieno [2,3-c]pyridine-2-carboxamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

3-methyloxetan-3-yl 6-(2-(furo [2,3-c]pyridine-2-carboxamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

6-(2-((E)-3-(6-aminopyridin-3-yl)acrylamido)ethyl)-N-benzyl-3-azabicyclo[3.1.0]hexane-3-carboxamide;

(E)-3-(6-aminopyridin-3-yl)-N-(2-(3-(morpholine-4-carbonyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

N-(2-(3-benzoyl-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) furo [2,3-c]pyridine-2-carboxamide;

6-(2-((E)-3-(6-aminopyridin-3-yl)acrylamido)ethyl)-N-phenyl-3-azabicyclo[3.1.0]hexane-3-carboxamide;

6-(2-((E)-3-(6-aminopyridin-3-yl)acrylamido)ethyl)-N-(tetrahydro-2H-pyran-4-yl)-3-azabicyclo[3.1.0]hexane-3-carboxamide;

6-(2-((E)-3-(6-aminopyridin-3-yl)acrylamido)ethyl)-N,N-diethyl-3-azabicyclo[3.1.0]hexane-3-carboxamide;

cyclopentyl 6-(2-((E)-3-(6-aminopyridin-3-yl)acrylamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

3-methyloxetan-3-yl 6-(2-((E)-3-(pyridin-4-yl)acrylamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

3-methyloxetan-3-yl 6-(2-(1H-pyrrolo [3,2-c]pyridine-2-carboxamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

3-methyloxetan-3-yl 6-(2-(thieno [3,2-c]pyridine-2-carboxamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

3-methyloxetan-3-yl 6-(2-(imidazo [1,2-a]pyridine-6-carboxamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

(E)-3-(6-aminopyridin-3-yl)-N-(2-(3-(pyrrolidine-1-carbonyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

phenyl 6-(2-((E)-3-(6-aminopyridin-3-yl)acrylamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

tetrahydro-2H-pyran-4-yl 6-(2-((E)-3-(6-aminopyridin-3-yl)acrylamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

3-methyloxetan-3-yl 6-(2-(5-fluoroisoindoline-2-carboxamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

3-methyloxetan-3-yl 6-(2-(imidazo [1,2-a]pyrimidine-6-carboxamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

3-methyloxetan-3-yl 6-(2-(benzo [d]thiazole-6-carboxamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

(E)-3-(6-aminopyridin-3-yl)-N-(2-(3-(phenylsulfonyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

(E)-3-(6-aminopyridin-3-yl)-N-(2-(3-((4-fluorophenyl) sulfonyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

(E)-3-(6-aminopyridin-3-yl)-N-(2-(3-((tetrahydro-2H-pyran-4-yl) sulfonyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

(E)-3-(6-aminopyridin-3-yl)-N-(2-(3-(cyclopentylsulfonyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

3-methyloxetan-3-yl 6-(2-(2-aminobenzo [d]thiazole-6-carboxamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

3-methyloxetan-3-yl 6-(2-(5-(pyridin-3-yl) isoxazole-3-carboxamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

2,3-dihydro-1H-inden-2-yl 6-(2-((E)-3-(6-aminopyridin-3-yl)acrylamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

(1-methylpiperidin)-4-yl 6-(2-((E)-3-(6-aminopyridin-3-yl)acrylamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

3-methyloxetan-3-yl 6-(2-(2-(pyridin-3-yl)cyclopropanecarboxamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

3-methyloxetan-3-yl 6-(2-((E)-3-(2-aminopyrimidin-5-yl)acrylamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

3-methyloxetan-3-yl 6-(2-(1/-pyrazolo [3,4-b]pyridine-5-carboxamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

N-(2-(3-(tert-butylcarbamoyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) furo [2,3-c]pyridine-2-carboxamide;

N-(2-(3-(phenylcarbamoyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) furo [2,3-c]pyridine-2-carboxamide;

N-(2-(3-(morpholine-4-carbonyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) furo [2,3-c]pyridine-2-carboxamide;

N-(2-(3-((tetrahydro-2H-pyran-4-yl) carbamoyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) furo [2,3-c] pyridine-2-carboxamide;

N-(2-(3-(diethylcarbamoyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) furo [2,3-c]pyridine-2-carboxamide;

tetrahydro-2H-pyran-4-yl 6-(2-(furo [2,3-c]pyridine-2-carboxamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

3-methyloxetan-3-yl 6-(2-(thiazolo [5,4-c]pyridine-2-carboxamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

N-(2-(3-benzoyl-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) imidazo [1,2-a]pyridine-6-carboxamide;

N-(2-(3-(tert-butylcarbamoyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) imidazo [1,2-a]pyridine-6-carboxamide;

N-(2-(3-(phenylcarbamoyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) imidazo [1,2-a]pyridine-6-carboxamide;

N-(2-(3-(pyrrolidine-1-carbonyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) imidazo [1,2-a]pyridine-6-carboxamide;

tetrahydro-2H-pyran-4-yl 6-(2-(imidazo [1,2-a]pyridine-6-carboxamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

N-(2-(3-((tetrahydro-2H-pyran-4-yl) sulfonyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) imidazo [1,2-a]pyridine-6-carboxamide;

N-(2-(3-(neopentylcarbamoyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) furo [2,3-c]pyridine-2-carboxamide;

N-(2-(3-(pyrrolidine-1-carbonyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) furo [2,3-c]pyridine-2-carboxamide;

(cyclopentyl) 6-(2-(furo [2,3-c]pyridine-2-carboxamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

N-(2-(3-((4-fluorophenyl) sulfonyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) furo [2,3-c]pyridine-2-carboxamide;

N-(2-(3-((tetrahydro-2H-pyran-4-yl) sulfonyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) furo [2,3-c] pyridine-2-carboxamide;

3-methyloxetan-3-yl 6-(2-(5-aminothieno [2,3-c]pyridine-2-carboxamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

N-(tert-butyl)-6-(2-((E)-3-(pyridin-3-yl)acrylamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxamide;

N-(2-(3-benzoyl-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) imidazo [1,2-a]pyrimidine-6-carboxamide;

N-(2-(3-(tert-butylcarbamoyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) imidazo [1,2-a]pyrimidine-6-carboxamide;

N-(2-(3-(phenylcarbamoyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) imidazo [1,2-a]pyrimidine-6-carboxamide;

tetrahydro-2H-pyran-4-yl 6-(2-(imidazo [1,2-a]pyrimidine-6-carboxamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

N-(2-(3-((tetrahydro-2H-pyran-4-yl) sulfonyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) imidazo [1,2-a]pyrimidine-6-carboxamide;

N-(2-(3-(tert-butylcarbamoyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-5-(pyridin-3-yl) isoxazole-3-carboxamide;

N-(2-(3-(tert-butylcarbamoyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-1H-pyrrolo [3,2-c]pyridine-2-carboxamide;

tetrahydro-2H-pyran-4-yl 6-(2-(1H-pyrrolo [3,2-c]pyridine-2-carboxamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

N-(2-(3-((tetrahydro-2H-pyran-4-yl) sulfonyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-1H-pyrrolo [3,2-c]pyridine-2-carboxamide;

tetrahydro-2H-pyran-4-yl 6-(2-(thieno [2,3-c]pyridine-2-carboxamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

(E)-3-(6-aminopyridin-3-yl)-N-(2-(3-(4-fluorobenzoyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

(E)-3-(6-aminopyridin-3-yl)-N-(2-(3-(2,4-dimethyloxazole-5-carbonyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

(E)-3-(6-aminopyridin-3-yl)-N-(2-(3-(1,3,5-trimethyl-1H-pyrazole-4-carbonyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

(E)-3-(6-aminopyridin-3-yl)-N-(2-(3-(3-fluorobenzoyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

(E)-3-(6-aminopyridin-3-yl)-N-(2-(3-(4-(difluoromethoxy)benzoyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

(E)-3-(6-aminopyridin-3-yl)-N-(2-(3-(3-(difluoromethoxy)benzoyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

(E)-3-(6-aminopyridin-3-yl)-N-(2-(3-(4-methylnicotinoyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

(E)-3-(6-aminopyridin-3-yl)-N-(2-(3-(4-(1-methylpiperidin-4-yl)benzoyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

(E)-3-(6-aminopyridin-3-yl)-N-(2-(3-(2-(tetrahydro-2H-pyran-4-yl) acetyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

(E)-3-(6-aminopyridin-3-yl)-N-(2-(3-(tetrahydro-2H-pyran-4-carbonyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

6-(2-((E)-3-(6-aminopyridin-3-yl)acrylamido)ethyl)-N-neopentyl-3-azabicyclo[3.1.0]hexane-3-carboxamide;

N-(2-(3-(4-fluorobenzoyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) furo [2,3-c]pyridine-2-carboxamide;

N-(2-(3-(2,4-dimethyloxazole-5-carbonyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) furo [2,3-c]pyridine-2-carboxamide;

N-(2-(3-(2-(tetrahydro-2H-pyran-4-yl) acetyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) furo [2,3-c] pyridine-2-carboxamide;

N-(2-(3-(tetrahydro-2H-pyran-4-carbonyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) furo [2,3-c] pyridine-2-carboxamide;

N-(2-(3-(2-(tetrahydro-2H-pyran-4-yl) acetyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) imidazo [1,2-a] pyridine-6-carboxamide;

N-(2-(3-(4-fluorobenzoyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) imidazo [1,2-a]pyridine-6-carboxamide;

N-(2-(3-(2,4-dimethyloxazole-5-carbonyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) imidazo [1,2-a]pyridine-6-carboxamide;

(E)-3-(pyridin-3-yl)-N-((3-(2-(tetrahydro-2H-pyran-4-yl) acetyl)-3-azabicyclo[3.1.0]hexan-6-yl)methyl)acrylamide;

(E)-N-(2-(3-(2,4-dimethyloxazole-5-carbonyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

N-(2-(3-(2-(tetrahydro-2H-pyran-4-yl) acetyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) imidazo [1,2-a]pyrimidine-6-carboxamide;

N-(2-(3-(4-fluorobenzoyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) imidazo [1,2-a]pyrimidine-6-carboxamide;

N-(2-(3-(2,4-dimethyloxazole-5-carbonyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) imidazo [1,2-a]pyrimidine-6-carboxamide;

5-(pyridin-3-yl)-N-(2-(3-(2-(tetrahydro-2H-pyran-4-yl) acetyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) isoxazole-3-carboxamide;

N-(2-(3-(4-fluorobenzoyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-5-(pyridin-3-yl) isoxazole-3-carboxamide;

N-(2-(3-(2,4-dimethyloxazole-5-carbonyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-5-(pyridin-3-yl) isoxazole-3-carboxamide;

N-(2-(3-(2-(tetrahydro-2H-pyran-4-yl) acetyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-1H-pyrrolo [3,2-c] pyridine-2-carboxamide;

N-(2-(3-(2,4-dimethyloxazole-5-carbonyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-1H-pyrrolo [3,2-c] pyridine-2-carboxamide;

N-(2-(3-(2,4-dimethyloxazole-5-carbonyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) thieno [2,3-c]pyridine-2-carboxamide;

3-(6-(2-((E)-3-(pyridin-3-yl)acrylamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carbonyl)benzamide;

N-(2-(3-(3-carbamoylbenzoyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-1H-pyrrolo [3,2-c]pyridine-2-carboxamide;

(E)-N-(2-(3-phenyl-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

N-(2-(3-(pyrimidin-2-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) imidazo [1,2-a]pyridine-6-carboxamide;

N-(2-(3-(pyrimidin-2-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) furo [2,3-c]pyridine-2-carboxamide;

N-(2-(3-(benzo [d]thiazol-2-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) furo [2,3-c]pyridine-2-carboxamide;

N-(2-(3-(naphthalen-1-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) furo [2,3-c]pyridine-2-carboxamide;

N-(2-(3-(quinazolin-2-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) furo [2,3-c]pyridine-2-carboxamide;

(E)-3-(pyridin-3-yl)-N-(2-(3-(pyrimidin-2-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

(E)-N-(2-(3-(benzo [d]thiazol-2-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-3-(pyridin-3-yl)-N-(2-(3-(quinazolin-2-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

(E)-N-(2-(3-(naphthalen-1-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(3-fluorophenyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(3-methoxyphenyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

N-(2-(3-(3-methoxyphenyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) furo [2,3-c]pyridine-2-carboxamide;

5-(pyridin-3-yl)-N-(2-(3-(pyrimidin-2-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) isoxazole-3-carboxamide;

(E)-3-(pyridin-3-yl)-N-(2-(3-(o-tolyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

(E)-N-(2-(3-(2,6-dimethylphenyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

N-(2-(3-phenyl-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-5-(pyridin-3-yl) isoxazole-3-carboxamide;

(E)-N-(2-(3-(2-cyanophenyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(3-cyanophenyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(4-cyanophenyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-3-(pyridin-3-yl)-N-(2-(3-(3-(trifluoromethyl)phenyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

(E)-3-(pyridin-3-yl)-N-(2-(3-(4-(trifluoromethyl)phenyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

(E)-3-(pyridin-3-yl)-N-(2-(3-(2-(trifluoromethyl)phenyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

(E)-N-(2-(3-(isoquinolin-7-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(isoquinolin-6-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-3-(pyridin-3-yl)-N-(2-(3-(quinolin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

(E)-N-(2-(3-(2-chlorophenyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(3-chlorophenyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(4-chlorophenyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3˜ (3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(3,5-dichlorophenyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-3-(pyridin-3-yl)-N-(2-(3-(pyridin-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

(E)-N-(2-(3-(5-chloro-2-fluorophenyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(3-(methylthio)phenyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(3-(methylsulfonyl)phenyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(3-chloro-4-fluorophenyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-3-(pyridin-3-yl)-N-(2-(3-(pyridin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

(E)-N-(2-(3-(3-(tert-butyl)phenyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(3-(tert-butoxy)phenyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-3-(pyridin-3-yl)-N-(2-(3-(2-(trifluoromethyl) pyridin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

(E)-N-(2-(3-(2-chloropyridin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(2-methoxypyridin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-3-(pyridin-3-yl)-N-(2-(3-(5-(trifluoromethyl)pyrimidin-2-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

(E)-N-(2-(3-(5-fluoropyrimidin-2-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(5-chloropyrimidin-2-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-3-(6-aminopyridin-3-yl)-N-(2-(3-(quinazolin-2-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

(E)-N-(2-(3-(7,8-dihydro-5H-pyrano [4,3-d]pyrimidin-2-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(6-fluoroquinazolin-2-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-3-(pyridin-3-yl)-N-(2-(3-(pyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

(E)-3-(pyridin-3-yl)-N-(2-(3-(4-(trifluoromethyl)pyrimidin-2-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

(E)-N-(2-(3-(1,3,5-triazin-2-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

2-(6-(2-((E)-3-(pyridin-3-yl)acrylamido)ethyl)-3-azabicyclo[3.1.0]hexan-3-yl)pyrimidine-4-carboxamide;

(E)-N-(2-(3-(2-chloro-5-fluoropyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(5-fluoro-4-methoxypyrimidin-2-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

2-(6-(2-((E)-3-(pyridin-3-yl)acrylamido)ethyl)-3-azabicyclo[3.1.0]hexan-3-yl)pyrimidine-5-carboxamide;

(E)-3-(pyridin-3-yl)-N-(2-(3-(4-(trifluoromethyl) thiazol-2-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

(E)-N-(2-(3-(pyridin-2-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(pyrazin-2-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

3-(6-(2-((E)-3-(6-aminopyridin-3-yl)acrylamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carbonyl)benzoic acid;

4-(6-(2-((E)-3-(6-aminopyridin-3-yl)acrylamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carbonyl)benzoic acid;

3-(6-(2-(furo [2,3-c]pyridine-2-carboxamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carbonyl)benzoic acid;

3-(6-(2-(imidazo [1,2-a]pyridine-6-carboxamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carbonyl)benzoic acid;

3-(6-(2-(imidazo [1,2-a]pyrimidine-6-carboxamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carbonyl)benzoic acid;

3-(6-(2-((E)-3-(pyridin-3-yl)acrylamido)ethyl)-3-azabicyclo[3.1.0]hexan-3-yl)benzamide;

(E)-N-(2-(3-(3-acetamidophenyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(3-(methylsulfonamido)phenyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

4-(6-(2-((E)-3-(pyridin-3-yl)acrylamido)ethyl)-3-azabicyclo[3.1.0]hexan-3-yl)benzamide;

(E)-N-(2-(3-(5-fluoro-4-hydroxypyrimidin-2-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(4-chloro-5-fluoropyrimidin-2-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-3-(6-aminopyridin-3-yl)-N-(2-(3-(pyrimidin-2-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

(E)-3-(6-aminopyridin-3-yl)-N-(2-(3-(benzo [d]thiazol-2-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

(E)-3-(6-aminopyridin-3-yl)-N-(2-(3-(naphthalen-1-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

(E)-3-(6-aminopyridin-3-yl)-N-(2-(3-phenyl-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

N-(2-(3-phenyl-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) furo [2,3-c]pyridine-2-carboxamide;

N-(2-(3-(pyrimidin-2-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-1H-pyrrolo [3,2-c]pyridine-2-carboxamide;

(E)-N-(2-(3-(4-fluorophenyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

N-(2-(3-(4-fluorophenyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) furo [2,3-c]pyridine-2-carboxamide;

N-(2-(3-(3-fluorophenyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) furo [2,3-c]pyridine-2-carboxamide;

N-(2-(3-phenyl-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-1H-pyrrolo [3,2-c]pyridine-2-carboxamide;

N-(2-(3-(pyrimidin-2-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) imidazo [1,2-a]pyrimidine-6-carboxamide;

N-(2-(3-(pyrimidin-2-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) thieno [2,3-c]pyridine-2-carboxamide;

(E)-3-(6-aminopyridin-3-yl)-N-(2-(3-(3-fluorophenyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

(E)-3-(6-aminopyridin-3-yl)-N-(2-(3-(3-(trifluoromethyl)phenyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

N-(2-(3-(2-chloro-5-fluoropyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) imidazo [1,2-a]pyridine-6-carboxamide;

N-(2-(3-(2-chloro-5-fluoropyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-1H-pyrrolo [3,2-c] pyridine-2-carboxamide;

(E)-N-(2-(3-(2-chloro-5-fluoropyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(6-chloropyridin-3-yl)acrylamide;

(E)-3-(6-aminopyridin-3-yl)-N-(2-(3-(2-chloro-5-fluoropyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

N-(2-(3-(2-chloro-5-fluoropyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl) propanamide;

N-(2-(3-(2-chloro-5-fluoropyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-5-(pyridin-3-yl) isoxazole-3-carboxamide;

(E)-N-(2-(3-(2-chloro-5-fluoropyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-2-yl)acrylamide;

N-(2-(3-(2-chloro-5-fluoropyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) cinnamamide;

(E)-N-(2-(3-(2-chloro-5-fluoropyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(6-hydroxypyridin-3-yl)acrylamide;

(E)-N-(2-(3-(2-chloro-5-fluoropyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(6-methoxypyridin-3-yl)acrylamide;

N-(2-(3-(2-chloro-5-fluoropyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) imidazo [1,2-a]pyrimidine-6-carboxamide;

(E)-N-(2-(3-(2-chloro-5-fluoropyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-4-yl)acrylamide;

N-(2-(3-(2-chloro-5-fluoropyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-4-yl) propanamide;

N-(2-(3-(2-chloro-5-fluoropyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-[1,2,4]triazolo [4,3-a]pyridine-6-carboxamide;

N-(2-(3-(2-chloro-5-fluoropyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-[1,2,4]triazolo [1,5-a]pyridine-6-carboxamide;

N-(2-(3-(2-chloro-5-fluoropyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-2-yl) propanamide;

N-(2-(3-(2-chloro-5-fluoropyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-2-(pyridin-3-yloxy) acetamide;

N-(2-(3-(2-chloro-5-fluoropyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) thieno [2′,3′: 4,5] imidazo [2,1-b]thiazole-2-carboxamide;

N-(2-(3-(2-chloro-5-fluoropyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) furo [2,3-c]pyridine-2-carboxamide;

(E)-N-(2-(3-(2-chloro-5-fluoropyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(6-fluoropyridin-3-yl)acrylamide;

N-(2-(3-(2-chloro-5-fluoropyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) thieno [2,3-c] pyridine-2-carboxamide;

N-(2-(3-(2-chloro-5-fluoropyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-1H-pyrazolo [3,4-b] pyridine-5-carboxamide;

N-(2-(3-(2-chloro-5-fluoropyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) isoindoline-2-carboxamide;

N-(2-(3-(2-chloro-5-fluoropyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-1H-pyrrolo [3,4-c] pyridine-2 (3H)-carboxamide;

N-(2-(3-(2-chloro-5-fluoropyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-5H-pyrrolo [3,4-b] pyridine-6 (7H)-carboxamide;

(E)-1-(2-(3-benzoyl-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-2-cyano-3-(pyridin-4-yl)guanidine;

3-methyloxetan-3-yl 6-(2-((E)-2-cyano-3-(pyridin-4-yl)guanidino)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

3-methyloxetan-3-yl 6-(2-(isoindoline-2-carboxamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

(E)-N-((3-benzoyl-3-azabicyclo[3.1.0]hexan-6-yl)methyl)-3-(pyridin-3-yl)acrylamide;

tert-butyl 6-((1-((E)-3-(6-aminopyridin-3-yl)acrylamido)cyclopropyl)methyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

tert-butyl 6-((1-((E)-3-(pyridin-3-yl)acrylamido)cyclopropyl)methyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

(E)-N-(2-(3-benzyl-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-3-(pyridin-3-yl)-N-(2-(3-(4-(trifluoromethyl)benzyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

(E)-N-(2-(3-isopropyl-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-3-(pyridin-3-yl)-N-(2-(3-((tetrahydro-2H-pyran-4-yl)methyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

(E)-N-(2-(3-(4-fluorobenzyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(2,4-difluorobenzyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(1-phenylethyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(4-fluorophenethyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2˜ (3-(3,5-dichlorobenzyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

tert-butyl 6-(2-((E)-3-(6-aminopyridin-3-yl)acrylamido)-1-hydroxyethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

tert-butyl 6-(1-hydroxy-2-((E)-3-(pyridin-3-yl)acrylamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

tert-butyl 6-(2-((E)-3-(6-aminopyridin-3-yl)acrylamido)-1-fluoroethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

tert-butyl 6-(1-fluoro-2-((E)-3-(pyridin-3-yl)acrylamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

(E)-N-(2-(2-oxo-3-phenyl-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-benzyl-2-oxo-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-3-(6-aminopyridin-3-yl)-N-(2-(3-benzyl-2-oxo-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

(E)-3-(6-aminopyridin-3-yl)-N-(2-(2-oxo-3-phenyl-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

N-(2-(2-oxo-3-phenyl-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) furo [2,3-c]pyridine-2-carboxamide;

N-(2-(2-oxo-3-phenyl-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-5-(pyridin-3-yl) isoxazole-3-carboxamide;

(E)-N-(2-(2-oxo-3-(3-(trifluoromethyl)phenyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-3-(6-aminopyridin-3-yl)-N-(2-(2-oxo-3-(3-(trifluoromethyl)phenyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

(E)-N-(2-(3-(4-fluorophenyl)-2-oxo-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

N-(2-(3-(4-fluorophenyl)-2-oxo-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-5-(pyridin-3-yl) isoxazole-3-carboxamide;

N-(2-(3-(4-fluorophenyl)-2-oxo-3-azabicyclo[3.1.0]hexan-6-yl)ethyl) isoindoline-2-carboxamide;

(E)-N-(2-(3-benzhydryl-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(5-fluoro-2-morpholinopyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(2-(cyclopentyloxy)-5-fluoropyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

tert-butyl 6-(2-((E)-3-(pyridin-3-yl)acrylamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

(E)-N-(2-(3-benzyl-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-phenyl-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

2-((5-fluoro-4-(6-(2-((E)-3-(pyridin-3-yl)acrylamido)ethyl)-3-azabicyclo[3.1.0]hexan-3-yl)pyrimidin-2-yl)oxy) acetic acid;

(E)-N-(2-(3-(2-amino-2-oxo-1-phenylethyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

3-((E)-3-((2-(3-(2-chloro-5-fluoropyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)amino)-3-oxoprop-1-en-1-yl)pyridine 1-oxide;

(E)-N-(2-(3-(2-(2-amino-2-oxoethoxy)-5-fluoropyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(2-hydroxy-1-phenylethyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(5-fluoro-2-phenylpyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(3-(dimethylphosphoryl)phenyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-benzyl-6-fluoro-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-3-(6-aminopyridin-3-yl)-N-(2-(6-fluoro-3-(pyrimidin-2-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

tert-butyl 6-fluoro-6-(2-((E)-3-(pyridin-3-yl)acrylamido)ethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate;

(E)-N-(2-(3-(2-chloro-5-fluoropyrimidin-4-yl)-6-fluoro-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

6-(2-((E)-3-(6-aminopyridin-3-yl)acrylamido)ethyl)-N-(tert-butyl)-3-azabicyclo[3.1.0]hexane-3-carboxamide;

(E)-3-(pyridin-3-yl)-N-(2-(3-(pyrimidin-2-ylmethyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

(E)-N-(2-(3-phenethyl-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-3-(pyridin-3-yl)-N-(2-(3-(2,2,2-trifluoro-1-phenylethyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

(E)-N-(2-(3-(5-fluoro-2-methoxypyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-3-(pyridin-3-yl)-N-(2-(3-(pyrimidin-5-ylmethyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

(E)-N-(2-(3-(2-(difluoromethoxy)pyridin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(2-chlorobenzyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(3-chlorobenzyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(4-chlorobenzyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(5-fluoro-2-isopropoxypyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(2-(dimethylamino)-5-fluoropyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)pyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(5-fluoro-2-phenoxypyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(2,6-dimethylpyridin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(2-(benzyloxy)-5-fluoropyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

methyl 2-phenyl-2-(6-(2-((E)-3-(pyridin-3-yl)acrylamido)ethyl)-3-azabicyclo[3.1.0]hexan-3-yl)acetate;

(E)-3-(pyridin-3-yl)-N-(2-(3-(2-((tetrahydro-2H-pyran-4-yl)oxy)pyridin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

(E)-N-(2-(3-(2-(2-(dimethylamino)ethoxy)-5-fluoropyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(2-amino-5-fluoropyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin˜3-yl)acrylamide;

(E)-N-(2-(3-(5-fluoro-2-methoxypyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(6-fluoropyridin-3-yl)acrylamide;

(E)-N-(2-(3-(5-fluoro-2-(2-hydroxyethoxy)pyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-3-(pyridin-3-yl)-N-(2-(3-(1-(pyrimidin-2-yl)ethyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

(E)-N-(2-(3-((2-chioropyrimidin-5-yl)methyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(2-(methylamino)-2-oxo-1-phenylethyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(2-(diethylamino)-2-oxo-1-phenylethyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-3-(pyridin-3-yl)-N-(2-(3-(1-(pyridin-4-yl)ethyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

(E)-3-(pyridin-3-yl)-N-(2-(3-(1-(pyridin-3-yl)ethyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

(E)-N-(2-(3-(1-(pyridin-2-yl)ethyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(1-(4-fluorophenyl)ethyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(1-(3-fluorophenyl)ethyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(5-fluoro-2-(piperazin-1-yl)pyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(5-fluoro-2-(4-methylpiperazin-1-yl)pyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(5-fluoro-2-(3-hydroxypyrrolidin-1-yl)pyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(5-fluoro-2-(methylamino)pyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(5-fluoro-2-(2-(methylamino)-2-oxoethoxy)pyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(2-(2-(diethylamino)-2-oxoethoxy)-5-fluoropyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(5-fluoro-2-methoxypyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(5-fluoropyridin-3-yl)acrylamide;

(E)-N-(2-(3-(5-fluoro-2-(2-morpholinoethoxy)pyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(5-fluoro-2-methoxypyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(4-fluoropyridin-3-yl)acrylamide;

(E)-N-(2-(3-(5-fluoro-2-(3-oxopiperazin-1-yl)pyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(2-methylbenzo [d]oxazol-7-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(phenyl(tetrahydro-2H-pyran-4-yl)methyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(5-fluoro-2-(oxazol-2-yl)pyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

(E)-N-(2-(3-(1H-indazol-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide;

diethyl(3-(6-(2-(E)-3-(pyridin-3-yl)acrylamido)ethyl)-3-azabicyclo[3.1.0]hexan-3-yl)phenyl)phosphonate;

(E)-3-(6-aminopyridin-3-yl)-N-(2-(3-(2-methoxypyridin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

(E)-3-(6-aminopyridin-3-yl)-N-(2-(3-(1˜ (4-fluorophenyl)ethyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

(E)-3-(6-aminopyridin-3-yl)-N-(2-(3-(4-fluorophenyl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)acrylamide;

(E)-N-(2-(3-(2-methyloxazolo[4,5-b]pyridin-7-yl)-3-azabicyclo[3.1.0]hexan-6-yl)ethyl)-3-(pyridin-3-yl)acrylamide; or

a pharmaceutically acceptable salt thereof.