	US 12,420,233 B2
	Raw material liquid concentration system
Mitsuru Fujita, Tokyo (JP); Masato Mikawa, Tokyo (JP); and Daisuke Hotta, Tokyo (JP)
Assigned to Asahi Kasei Kabushiki Kaisha, Tokyo (JP)
Appl. No. 17/614,085
Filed by Asahi Kasei Kabushiki Kaisha, Tokyo (JP)
PCT Filed May 29, 2020, PCT No. PCT/JP2020/021444 § 371(c)(1), (2) Date Nov. 24, 2021, PCT Pub. No. WO2020/241865, PCT Pub. Date Dec. 3, 2020.
Claims priority of application No. 2019-102656 (JP), filed on May 31, 2019; and application No. 2020-040211 (JP), filed on Mar. 9, 2020.
Prior Publication US 2022/0226777 A1, Jul. 21, 2022
Int. Cl. B01D 61/02 (2006.01); A61K 38/05 (2006.01); B01D 61/00 (2006.01); B01D 61/36 (2006.01); B01D 63/04 (2006.01); B01D 69/08 (2006.01); B01D 69/10 (2006.01); B01D 69/12 (2006.01); B01D 71/68 (2006.01)

CPC B01D 61/002 (2013.01) [A61K 38/05 (2013.01); B01D 61/364 (2013.01); B01D 63/04 (2013.01); B01D 69/08 (2013.01); B01D 69/087 (2013.01); B01D 69/10 (2013.01); B01D 69/12 (2013.01); B01D 69/1251 (2022.08); B01D 71/68 (2013.01)]

13 Claims

1. A raw material liquid concentration method for a pharmaceutical production process, the method having:

a first step wherein a raw material liquid containing a solvent and a solute and a draw solution containing a draw substance are contacted via a forward osmosis membrane to move the solvent in the raw material liquid into the draw solution and move the draw substance in the draw solution into the raw material liquid to obtain a concentrated raw material liquid and a diluted draw solution, wherein a ratio (permeation flux of the draw substance [g/(m²×hr)]/permeation flux of the solvent [L/m²×hr)]) of a permeation flux of the draw substance, by which the draw substance in the draw solution is moved into the raw material liquid, to a permeation flux of the solvent, by which the solvent in the raw material liquid is moved into the draw solution, in the first step is 3 [g/L] or less.