US 12,420,118 B2
Histotripsy systems and methods
Ryan M. Miller, Saline, MI (US); Alexander P. Duryea, Ann Arbor, MI (US); Jonathan M. Cannata, Ann Arbor, MI (US); Zeljko Mladenovic, Orefield, PA (US); Dejan Teofilovic, Ann Arbor, MI (US); Aleksandra Rakic, Ann Arbor, MI (US); and Joshua Stopek, Minneapolis, MN (US)
Assigned to HistoSonics, Inc., Plymouth, MN (US)
Filed by HistoSonics, Inc., Plymouth, MN (US)
Filed on Sep. 11, 2023, as Appl. No. 18/464,877.
Application 18/464,877 is a continuation of application No. 16/698,587, filed on Nov. 27, 2019, granted, now 11,813,484.
Claims priority of provisional application 62/772,473, filed on Nov. 28, 2018.
Prior Publication US 2024/0001158 A1, Jan. 4, 2024
Int. Cl. A61N 7/00 (2006.01); A61B 8/08 (2006.01); A61B 17/22 (2006.01)
CPC A61N 7/00 (2013.01) [A61B 8/085 (2013.01); A61B 2017/22008 (2013.01); A61N 2007/0039 (2013.01); A61N 2007/0052 (2013.01)] 22 Claims
OG exemplary drawing
 
1. A method of applying histotripsy treatment, comprising the steps of:
identifying a target tissue volume of a subject;
dividing the target tissue volume into a plurality of focal zones arranged within a plurality of radial layers, wherein the plurality of focal zones cover at least 90% of the target tissue volume;
determining a treatment path through the plurality of radial layers that comprises moving sequentially through the plurality of focal zones for a given radial layer before moving to an adjacent radial layer;
generating a treatment plan that includes the plurality of focal zones, the plurality of radial layers, and the treatment path, and an anticipated thermal profile for the treatment plan; and
mechanically moving a focus of an ultrasound therapy array with a robotic positioning system that is coupled to the ultrasound therapy transducer array and delivering histotripsy pulses to each of the plurality of focal zones according to the treatment plan such that at least 90% of the target tissue volume is mechanically solubilized.