US 12,420,116 B2
Methods and systems for using and controlling higher dose rate ionizing radiation in short time intervals
Kenneth W. Brooks, Windermere, FL (US); James A. Nelson, Newark, CA (US); Derek T. DeScioli, San Jose, CA (US); Christopher J. Patane, San Mateo, CA (US); and Donald A. Goer, Sunnyvale, CA (US)
Assigned to IntraOp Medical Corporation, Sunnyvale, CA (US)
Appl. No. 17/642,554
Filed by IntraOp Medical Corporation, Sunnyvale, CA (US)
PCT Filed Sep. 9, 2020, PCT No. PCT/US2020/049925
§ 371(c)(1), (2) Date Mar. 11, 2022,
PCT Pub. No. WO2021/050535, PCT Pub. Date Mar. 18, 2021.
Claims priority of provisional application 62/986,104, filed on Mar. 6, 2020.
Claims priority of provisional application 62/900,505, filed on Sep. 14, 2019.
Prior Publication US 2022/0323793 A1, Oct. 13, 2022
Int. Cl. A61N 5/10 (2006.01)
CPC A61N 5/1067 (2013.01) [A61N 5/1071 (2013.01); A61N 5/1077 (2013.01)] 42 Claims
OG exemplary drawing
 
1. An ionization radiation system that deposits a target dose of pulsed ionizing radiation into a substrate during a treatment, said ionization radiation system comprising:
a. a pulsed ionizing radiation beam that is aimed at and deposits ionizing radiation into the substrate during the treatment, wherein the pulsed ionizing radiation beam comprises fluence characteristics as the treatment proceeds; and
b. a control system comprising at least one sensor that monitors the pulsed ionizing radiation beam as the treatment proceeds, wherein the at least one sensor comprises a toroid sensor, and wherein:
i. the toroid sensor provides an output signal indicative of the fluence characteristics of the pulsed ionizing radiation beam as the treatment proceeds;
ii. the control system comprises program instructions that use information comprising the output signal to determine dose information indicative of the cumulative dose of the ionizing radiation that is deposited into the substrate as the treatment proceeds;
iii. the toroid sensor has a central bore, and the pulsed ionizing radiation beam passes through the central bore of the toroid sensor;
iv. the control system comprises program instructions that, as the target dose approaches as the treatment proceeds, proactively adjust a pulse duration of the pulsed ionizing radiation beam so that the cumulative dose deposited into the substrate matches the target dose when the depositing of the pulsed ionizing radiation into the substrate is terminated; and
v. the control system comprises program instructions, that as the target dose approaches, issue a stop signal in advance of reaching the target dose that causes the depositing of the pulsed ionizing radiation into the substrate to be terminated when the target dose is reached.