| CPC A61M 60/139 (2021.01) [A61M 60/295 (2021.01); A61M 60/427 (2021.01); A61M 60/577 (2021.01)] | 27 Claims |

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1. A heart assist device comprising:
a flexible catheter shaft having a proximal end and a distal end;
an expandable and collapsible cup coupled to the distal end of the catheter shaft and having a pumping chamber;
an inflow section and an outflow section each being in communication with the pumping chamber, wherein the inflow section has an inlet and the outflow section has an outlet, wherein the inflow and outflow sections each has a size and a shape such that when the inlet is in a heart chamber upstream of a heart valve, the outlet is positioned in a vascular lumen downstream of the heart valve;
a one-way valve configured to open to allow blood flow through the inlet into the pumping chamber and further configured to close to block blood flow through the inlet out of the pumping chamber; and
a pumping mechanism in the cup configured to operate cyclically between an inflow phase and an ejection phase to displace blood from the pumping chamber through the outlet, wherein the one-way valve is open during the inflow phase and closed during at least a first portion of the ejection phase, and wherein during a second portion of the ejection phase blood is drawn through the inlet into the pumping chamber while blood exits the pumping chamber;
wherein the pumping mechanism is configured to operate cyclically between the inflow phase and the ejection phase at a frequency of at least 100 cycles per minute.
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