US 12,420,072 B2
Systems and methods for cross-linking treatments of an eye
Marc D. Friedman, Needham, MA (US); Alexandra Nicklin, Cambriedge, MA (US); and Pavel Kamaev, Lexington, MA (US)
Assigned to Avedro, Inc., Waltham, MA (US)
Filed by Avedro, Inc., Waltham, MA (US)
Filed on Aug. 8, 2022, as Appl. No. 17/883,302.
Application 17/883,302 is a division of application No. 16/324,489, granted, now 11,406,805, previously published as PCT/US2017/045866, filed on Aug. 8, 2017.
Claims priority of provisional application 62/433,053, filed on Dec. 12, 2016.
Claims priority of provisional application 62/372,290, filed on Aug. 8, 2016.
Prior Publication US 2023/0129652 A1, Apr. 27, 2023
Int. Cl. A61M 37/00 (2006.01); A61F 9/00 (2006.01); A61F 9/007 (2006.01); A61F 9/008 (2006.01); A61N 5/06 (2006.01)
CPC A61M 37/00 (2013.01) [A61F 9/0017 (2013.01); A61F 9/007 (2013.01); A61F 9/008 (2013.01); A61F 9/00802 (2013.01); A61F 9/00804 (2013.01); A61N 5/062 (2013.01); A61F 2009/00844 (2013.01); A61F 2009/00872 (2013.01); A61F 2009/00893 (2013.01); A61F 2009/00895 (2013.01); A61M 2037/0007 (2013.01); A61M 2037/0046 (2013.01); A61M 2205/051 (2013.01); A61M 2210/0612 (2013.01)] 17 Claims
OG exemplary drawing
 
1. A method for treating an eye, comprising:
determining an area at a surface of a cornea for delivery of a cross-linking agent;
disrupting tissue at the area at the surface of the cornea for partial epithelial disruption, including disrupting apical layers of superficial squamous cells of the cornea, wherein the disrupting the tissue at the area at the surface of the cornea includes disrupting the cornea up to a depth of no greater than approximately 25 μm;
applying a cross-linking agent to the area at the surface of the cornea, the cross-linking agent being transmitted through a disrupted area at a greater rate relative to non-disrupted areas of the cornea; and
delivering photoactivating light to the cornea, the photoactivating light activating the cross-linking agent to generate cross-linking activity in the cornea.