US 12,420,037 B2
Systems, devices and methods for modulating a respiratory drive of a patient
Christer Sinderby, Toronto (CA); Jennifer Beck, Toronto (CA); and Norman Comtois, Scarborough (CA)
Assigned to UNITY HEALTH TORONTO, Toronto (CA)
Appl. No. 17/277,780
Filed by UNITY HEALTH TORONTO, Toronto (CA)
PCT Filed Sep. 19, 2019, PCT No. PCT/CA2019/051329
§ 371(c)(1), (2) Date Mar. 19, 2021,
PCT Pub. No. WO2020/056511, PCT Pub. Date Mar. 26, 2020.
Claims priority of provisional application 62/733,377, filed on Sep. 19, 2018.
Prior Publication US 2021/0346623 A1, Nov. 11, 2021
Int. Cl. A61M 16/00 (2006.01); A61M 16/06 (2006.01)
CPC A61M 16/0003 (2014.02) [A61M 16/0051 (2013.01); A61M 16/0672 (2014.02); A61M 2205/502 (2013.01); A61M 2210/1014 (2013.01); A61M 2230/04 (2013.01); A61M 2230/40 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A mechanical ventilation system for modulating a respiratory drive of a patient, comprising:
a plurality of ventilation therapy sub-systems, including a synchronized airway CO2 dilution (AwCO2Dil) sub-system, wherein, each of the ventilation therapy sub-systems implement corresponding functions adapted to assist a corresponding reduction of the respiratory drive of the patient;
a detector of the respiratory drive of the patient;
an operator interface configured to receive one or more control parameters, the one or more control parameters include a maximum respiratory drive value and a respiratory drive rise time increase limit; and
each of the therapeutic contributions represents a share of an excess of the respiratory drive of the patient above the maximum respiratory drive value to be controlled by a respective one of the plurality of ventilation therapy sub-systems; and
a main controller operatively connected to each of the plurality of ventilation therapy sub-systems, to the detector of the respiratory drive of the patient and to the operator interface, the main controller being configured to:
receive the one or more control parameters from the operator interface,
receive measurements from the detector of the respiratory drive of the patient,
assign, based on the respiratory drive of the patient and on the one or more control parameters, a therapeutic contribution to each of the plurality of ventilation therapy sub-systems for control of the respiratory drive of the patient, and
control each of the plurality of the ventilation therapy sub-systems according to its assigned therapeutic contribution;
the main controller being further configured to:
detect, at each breath of the patient, a peak and a rise time of the respiratory drive of the patient; and
implement a test stage comprising:
causing a pause of at least one of the plurality of ventilation therapy sub-systems,
comparing the rise time of the respiratory drive of the patient detected when the at least one of the plurality of ventilation therapy sub-systems is paused to the rise time of the respiratory drive of the patient detected when the at least one of the plurality of ventilation therapy sub-systems is not paused to detect an increase of the respiratory drive rise time of the patient, and
ending the test stage after detecting the increase of the respiratory drive rise time.