US 12,420,018 B2
Devices and processes for delivery of therapeutic fluids
William Godwin Atterbury, Columbus, OH (US); Corrie Jo Bennison, Lewis Center, OH (US); Jeffrey Leclair Ellis, Columbus, OH (US); David Arthur Holley, Lancaster, OH (US); Beverly Ann Piatt, Columbus, OH (US); and John Paul Tallarico, Powell, OH (US)
Assigned to Eli Lilly and Company, Indianapolis, IN (US)
Appl. No. 17/299,850
Filed by Eli Lilly and Company, Indianapolis, IN (US)
PCT Filed Dec. 12, 2019, PCT No. PCT/US2019/065904
§ 371(c)(1), (2) Date Jun. 4, 2021,
PCT Pub. No. WO2020/131552, PCT Pub. Date Jun. 25, 2020.
Claims priority of provisional application 62/781,662, filed on Dec. 19, 2018.
Prior Publication US 2022/0111147 A1, Apr. 14, 2022
Int. Cl. A61M 5/20 (2006.01); A61M 5/32 (2006.01)
CPC A61M 5/2046 (2013.01) [A61M 5/2033 (2013.01); A61M 5/3204 (2013.01); A61M 2005/2026 (2013.01); A61M 2005/208 (2013.01)] 17 Claims
OG exemplary drawing
 
1. A therapeutic agent delivery system, comprising:
a housing having a distal end portion;
a therapeutic agent delivery assembly carried by the housing, the therapeutic agent delivery assembly comprising:
a chamber comprising a passageway;
a therapeutic agent carried in the passageway;
a needle in communication with the passageway;
a pressure generating actuator including a mixing chamber and a shuttle carried by the mixing chamber,
the therapeutic agent delivery assembly being translatable relative to the housing from a stowed configuration to a deployed configuration, in the deployed configuration the needle at least partially extending distally from the distal end portion of the housing;
a user input configured to be actuated by a user, actuation of the user input translating the therapeutic agent delivery assembly from the stowed configuration to the deployed configuration;
an input restraint being rotatable relative to the housing from a first rotational configuration to a second rotational configuration, in the first rotational configuration the input restraint inhibiting actuation of the user input, and in the second rotational configuration the input restraint permitting actuation of the user input; and
a sleeve being translatable relative to the housing from an exposed configuration to a retracted configuration, in the exposed configuration the sleeve at least partially extending distally from the distal end portion of the housing, and the sleeve rotating the input restraint from the first rotational configuration to the second rotational configuration when translating from the exposed configuration to the retracted configuration,
wherein actuation of the user input causes the pressure generating actuator to pressurize the therapeutic agent, deliver the therapeutic agent from the passageway to the needle, and discharge the therapeutic agent from the needle, wherein pressure generating actuator pressurizes the therapeutic agent upon the shuttle rotating relative to the mixing chamber.