US 12,419,998 B2
Tuning adhesion at contacting device interfaces: geometric tools for minimizing surface fouling
William R. Wagner, Gibsonia, PA (US); Sachin Shankar Velankar, Pittsburgh, PA (US); Sang Ho Ye, Pittsburgh, PA (US); Edith Tzeng, Presto, PA (US); Luka Pocivavsek, Pittsburgh, PA (US); and Enrique Cerda, Santiago (CL)
Assigned to UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, Pittsburgh, PA (US); UNIVERSIDAD DE SANTIAGO DE CHILE, Santiago (CL); and UPMC, Pittsburgh, PA (US)
Appl. No. 16/340,157
Filed by UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, Pittsburgh, PA (US); UPMC, Pittsburgh, PA (US); and UNIVERSIDAD DE SANTIAGO DE CHILE, Santiago (CL)
PCT Filed Oct. 18, 2017, PCT No. PCT/US2017/057111
§ 371(c)(1), (2) Date Apr. 8, 2019,
PCT Pub. No. WO2018/075595, PCT Pub. Date Apr. 26, 2018.
Claims priority of provisional application 62/409,645, filed on Oct. 18, 2016.
Prior Publication US 2021/0236700 A1, Aug. 5, 2021
Int. Cl. B32B 7/022 (2019.01); A61F 2/06 (2013.01); A61L 27/26 (2006.01); A61L 29/04 (2006.01); A61L 33/06 (2006.01); B32B 1/08 (2006.01); B32B 3/28 (2006.01); B32B 37/10 (2006.01); B32B 37/16 (2006.01); B32B 38/00 (2006.01); B81C 1/00 (2006.01)
CPC A61L 33/062 (2013.01) [A61F 2/06 (2013.01); A61L 27/26 (2013.01); A61L 29/049 (2013.01); B32B 1/08 (2013.01); B32B 3/28 (2013.01); B32B 7/022 (2019.01); B32B 37/1054 (2013.01); B81C 1/00206 (2013.01); A61F 2210/0076 (2013.01); A61F 2240/001 (2013.01); A61F 2250/0018 (2013.01); A61L 2430/20 (2013.01); B32B 37/16 (2013.01); B32B 2038/0028 (2013.01); B32B 2309/16 (2013.01); B32B 2535/00 (2013.01); B81C 2201/0156 (2013.01); B81C 2201/0163 (2013.01)] 5 Claims
OG exemplary drawing
 
1. A method of actuating an anti-fouling surface of a vascular implant device to continually cycle between a smooth base topography and a deformed topography, and reverse to a smooth base top, comprising:
forming a vascular implant composite, comprising:
selecting a first layer composed of a first material having a surface topography and a first modulus;
providing an initial smooth base surface topography to the first layer;
selecting a second layer composed of a second material having a different second modulus,
wherein a ratio of the first modulus to the second modulus is from about 3:1 to about 10,000,000:1; and
connecting the second layer to the first layer;
cycling the surface topography of the first layer, comprising:
applying a mechanical strain to the vascular implant composite, comprising:
repeatedly actuating one or more wrinkles or folds to form one or more reversible deformed surface topographies on the first layer,
wherein the repeatedly actuating step is provided by continual variation of blood pressure between systol and diastole, and
wherein the surface topography of the first layer continually transitions between a smooth surface topography and one or more reversible deformed surface topographies as a result of the continual variation of blood pressure between systol and diastole in a natural circulatory system of a body.